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ACEIs and ARBs Treatment in Diabetic Patients -Drug Interactions and Adverse Drug Effects

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified January 2007 by Assaf-Harofeh Medical Center.
Recruitment status was:  Recruiting
Information provided by:
Assaf-Harofeh Medical Center Identifier:
First received: February 19, 2007
Last updated: February 20, 2007
Last verified: January 2007
Proteinuria is an expression of diabetic nephropaty in type 1 and type 2 patients. Hypertenshion treatment and decreasing urine protein excretion, slow down renal deterioration. Treating diabetic ,hypertensive patients with Angiotensin Converting Enzyme inhibitors (ACEi), Angiotensin receptor blockers (ARBs)is common practice. The aim of our work is to examine 1.The prevalence of ACE and ARB treatment in diabetic patients with or without hypertension.2. Adverse drug reactions of ACEi and ARBs alone or in combination.

Condition Phase
Diabetes Mellitus Type 2 Phase 4

Study Type: Observational
Study Design: Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Angiotensin Converting Enzyme Inhibitors & Angiotensin Receptor Blocker in the Treatment of Type 2 Diabetic Patients Adverse Drug Effects and Drug Interactions- a Survey in an Internal Medicine Department.

Resource links provided by NLM:

Further study details as provided by Assaf-Harofeh Medical Center:

Estimated Enrollment: 300
Study Start Date: January 2007
Estimated Study Completion Date: March 2007
Detailed Description:

The study group- men and women with diabetes mellitus type 2,who were hospitalized in the department of internal medicine in Assaf- Harofeh Medical Center.

During hospitalization, data regarding the clinical history,chronic diseases and drugs were collected from the medical files. Blood tests results were recorded during hospitalization .The patients were asked about adverse drug effects.


Ages Eligible for Study:   40 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Type 2 diabetic patients admitted to department of Internal Medicine in Assaf Harofeh Medical Center

Exclusion Criteria:

  • Type 1 diabetes mellitus
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00437775

Contact: Alina Alperovich, B.Pharm 972-547616736
Contact: Gabby Elbaz, MD 972-8-977-9240

Assaf Harofeh Medical Center Recruiting
Zerifin, Israel, 70300
Contact: Alina Alperovich, B.Pharm    972-547616736   
Sponsors and Collaborators
Assaf-Harofeh Medical Center
Study Director: Ahuva Golik, Assoc. Prof. Sackler School of Medicine, Tel-Aviv University
Principal Investigator: Alina Alperovich, B.Pharm Assaf-Harofeh Medical Center
Study Chair: Lila Akivison, MSc.Pharm Assaf-Harofeh Medical Center
Study Chair: Sofia Berkovitch, MSc. Pharm Assaf-Harofeh Medical Center
Study Chair: Gabby Elbaz, MD Assaf- Hrofech Medical Senter
  More Information

Publications: Identifier: NCT00437775     History of Changes
Other Study ID Numbers: 167/06
Study First Received: February 19, 2007
Last Updated: February 20, 2007

Keywords provided by Assaf-Harofeh Medical Center:
Diabetes Mellitus type 2
ACE Inhibitors
Adverse drug effect

Additional relevant MeSH terms:
Diabetes Mellitus
Diabetes Mellitus, Type 2
Drug-Related Side Effects and Adverse Reactions
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Chemically-Induced Disorders
Angiotensin-Converting Enzyme Inhibitors
Angiotensin Receptor Antagonists
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action processed this record on September 21, 2017