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Frequency of ICAM-1 Polymorphisms in Obese Subjects

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00436488
First Posted: February 19, 2007
Last Update Posted: February 19, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Istituto Auxologico Italiano
  Purpose
The genetic contribution to the development of obesity is now well recognized. However obesity is a polygenic disease and thus many genes are likely to be involved. This study aims to investigate the possible association between specific variants of the gene coding for the Intercellular Adhesion Molecule-1 (ICAM-1)and the development of severe obesity in an Italian population

Condition
Obesity

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Study of the Association Between ICAM-1 Polymorphisms and Severe Obesity

Further study details as provided by Istituto Auxologico Italiano:

Estimated Enrollment: 200
Study Start Date: January 2005
Estimated Study Completion Date: July 2006
Detailed Description:
Severely obese subjects referred to our institution will be evaluated. For the aim of the study, a venous blood sample will be obtained from these subjects and from a group of normal weight volunteers. Genomic DNA will be extracted from the blood samples and analysed by standard molecular biology techniques.The allelic and genotype frequencies of the two ICAM-1 variants will be calculated in the obese and control groups. The statistical significance of possible differences will be determined
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Obesity

Exclusion Criteria:

  • Associated inflammatory diseases
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00436488


Sponsors and Collaborators
Istituto Auxologico Italiano
Investigators
Principal Investigator: Anna Maria Di Blasio, MD Istituto Auxologico Italiano
  More Information

ClinicalTrials.gov Identifier: NCT00436488     History of Changes
Other Study ID Numbers: 12C501
First Submitted: February 16, 2007
First Posted: February 19, 2007
Last Update Posted: February 19, 2007
Last Verified: February 2007

Keywords provided by Istituto Auxologico Italiano:
ICAM-1
Obesity
Gene variants

Additional relevant MeSH terms:
Obesity
Overnutrition
Nutrition Disorders
Overweight
Body Weight
Signs and Symptoms