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Frequency of ICAM-1 Polymorphisms in Obese Subjects

This study has been completed.
Information provided by:
Istituto Auxologico Italiano Identifier:
First received: February 16, 2007
Last updated: NA
Last verified: February 2007
History: No changes posted
The genetic contribution to the development of obesity is now well recognized. However obesity is a polygenic disease and thus many genes are likely to be involved. This study aims to investigate the possible association between specific variants of the gene coding for the Intercellular Adhesion Molecule-1 (ICAM-1)and the development of severe obesity in an Italian population


Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Study of the Association Between ICAM-1 Polymorphisms and Severe Obesity

Further study details as provided by Istituto Auxologico Italiano:

Estimated Enrollment: 200
Study Start Date: January 2005
Estimated Study Completion Date: July 2006
Detailed Description:
Severely obese subjects referred to our institution will be evaluated. For the aim of the study, a venous blood sample will be obtained from these subjects and from a group of normal weight volunteers. Genomic DNA will be extracted from the blood samples and analysed by standard molecular biology techniques.The allelic and genotype frequencies of the two ICAM-1 variants will be calculated in the obese and control groups. The statistical significance of possible differences will be determined

Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Obesity

Exclusion Criteria:

  • Associated inflammatory diseases
  Contacts and Locations
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Please refer to this study by its identifier: NCT00436488

Sponsors and Collaborators
Istituto Auxologico Italiano
Principal Investigator: Anna Maria Di Blasio, MD Istituto Auxologico Italiano
  More Information Identifier: NCT00436488     History of Changes
Other Study ID Numbers: 12C501
Study First Received: February 16, 2007
Last Updated: February 16, 2007

Keywords provided by Istituto Auxologico Italiano:
Gene variants

Additional relevant MeSH terms:
Nutrition Disorders
Body Weight
Signs and Symptoms processed this record on August 18, 2017