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Expression of Steroid Receptors in Endometrium

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00436462
First Posted: February 19, 2007
Last Update Posted: November 9, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Aristotle University Of Thessaloniki
  Purpose
Expression of steroid receptors in endometrium during ovarian stimulation.

Condition
Endometrium

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Expression of Steroid Receptors in Endometrium During the Early Follicular Phase in Stimulated Cycles

Further study details as provided by Aristotle University Of Thessaloniki:

Primary Outcome Measures:
  • Steroid receptors expression in endometrium during early follicular phase [ Time Frame: 3 months ]

Secondary Outcome Measures:
  • In which day:day o+2, day 0+4 or day HCG [ Time Frame: 1 month ]

Biospecimen Retention:   Samples Without DNA
endometrial tissue

Estimated Enrollment: 30
Study Start Date: December 2005
Study Completion Date: December 2007
Primary Completion Date: December 2007 (Final data collection date for primary outcome measure)
Detailed Description:
The purpose of this study is to examine in stimulated cycles a) whether there is a difference in expression of steroid receptors in stroma and glands of endometrium between different days during the follicular phase b)whether there are secretory changes detected by endometrium histology before ovulation c)whether there is an association between expression of steroid receptors in endometrium and exposure to oestradiol and progesterone during the follicular phase.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 39 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
infertile women
Criteria

Inclusion Criteria:

  • Treatment by IUI,
  • BMI:18-29KGR/M2,
  • No previous ovarian surgery,
  • Normal hysterosalpingography,
  • Estradiol < 80pg/ml and progesterone < 1.6ng/ml on day 2 of the cycle

Exclusion Criteria:

  • Endometriosis,
  • Severe male factor
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00436462


Locations
Greece
Unit of Human Reproduction, 1st Department of Obstetrics & Gynecology, AUTH, Papageorgiou Hospital
Thessaloniki, Greece, 56429
Sponsors and Collaborators
Aristotle University Of Thessaloniki
Investigators
Study Director: Basil C Tarlatzis, MD,PhD Unit of Human Reproduction, 1st Department of Obst & Gyn, Aristotle University of Thessaloniki, Papageorgiou Hospital, Greece