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Expression of Steroid Receptors in Endometrium

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT00436462
Recruitment Status : Completed
First Posted : February 19, 2007
Last Update Posted : November 9, 2009
Sponsor:
Information provided by:
Aristotle University Of Thessaloniki

Brief Summary:
Expression of steroid receptors in endometrium during ovarian stimulation.

Condition or disease
Endometrium

Detailed Description:
The purpose of this study is to examine in stimulated cycles a) whether there is a difference in expression of steroid receptors in stroma and glands of endometrium between different days during the follicular phase b)whether there are secretory changes detected by endometrium histology before ovulation c)whether there is an association between expression of steroid receptors in endometrium and exposure to oestradiol and progesterone during the follicular phase.

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Study Type : Observational
Estimated Enrollment : 30 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Expression of Steroid Receptors in Endometrium During the Early Follicular Phase in Stimulated Cycles
Study Start Date : December 2005
Actual Primary Completion Date : December 2007
Actual Study Completion Date : December 2007



Primary Outcome Measures :
  1. Steroid receptors expression in endometrium during early follicular phase [ Time Frame: 3 months ]

Secondary Outcome Measures :
  1. In which day:day o+2, day 0+4 or day HCG [ Time Frame: 1 month ]

Biospecimen Retention:   Samples Without DNA
endometrial tissue


Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 39 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
infertile women
Criteria

Inclusion Criteria:

  • Treatment by IUI,
  • BMI:18-29KGR/M2,
  • No previous ovarian surgery,
  • Normal hysterosalpingography,
  • Estradiol < 80pg/ml and progesterone < 1.6ng/ml on day 2 of the cycle

Exclusion Criteria:

  • Endometriosis,
  • Severe male factor

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00436462


Locations
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Greece
Unit of Human Reproduction, 1st Department of Obstetrics & Gynecology, AUTH, Papageorgiou Hospital
Thessaloniki, Greece, 56429
Sponsors and Collaborators
Aristotle University Of Thessaloniki
Investigators
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Study Director: Basil C Tarlatzis, MD,PhD Unit of Human Reproduction, 1st Department of Obst & Gyn, Aristotle University of Thessaloniki, Papageorgiou Hospital, Greece
Publications:
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Responsible Party: Unit for Human Reproduction, Aristotle University of Thessaloniki
ClinicalTrials.gov Identifier: NCT00436462    
Other Study ID Numbers: UHR-4
First Posted: February 19, 2007    Key Record Dates
Last Update Posted: November 9, 2009
Last Verified: November 2009
Keywords provided by Aristotle University Of Thessaloniki:
Steroid receptors
Endometrium
IVF
Follicular phase