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Expression of Steroid Receptors in Endometrium

This study has been completed.
Information provided by:
Aristotle University Of Thessaloniki Identifier:
First received: February 16, 2007
Last updated: November 6, 2009
Last verified: November 2009
Expression of steroid receptors in endometrium during ovarian stimulation.


Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Expression of Steroid Receptors in Endometrium During the Early Follicular Phase in Stimulated Cycles

Further study details as provided by Aristotle University Of Thessaloniki:

Primary Outcome Measures:
  • Steroid receptors expression in endometrium during early follicular phase [ Time Frame: 3 months ]

Secondary Outcome Measures:
  • In which day:day o+2, day 0+4 or day HCG [ Time Frame: 1 month ]

Biospecimen Retention:   Samples Without DNA
endometrial tissue

Estimated Enrollment: 30
Study Start Date: December 2005
Study Completion Date: December 2007
Primary Completion Date: December 2007 (Final data collection date for primary outcome measure)
Detailed Description:
The purpose of this study is to examine in stimulated cycles a) whether there is a difference in expression of steroid receptors in stroma and glands of endometrium between different days during the follicular phase b)whether there are secretory changes detected by endometrium histology before ovulation c)whether there is an association between expression of steroid receptors in endometrium and exposure to oestradiol and progesterone during the follicular phase.

Ages Eligible for Study:   20 Years to 39 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
infertile women

Inclusion Criteria:

  • Treatment by IUI,
  • BMI:18-29KGR/M2,
  • No previous ovarian surgery,
  • Normal hysterosalpingography,
  • Estradiol < 80pg/ml and progesterone < 1.6ng/ml on day 2 of the cycle

Exclusion Criteria:

  • Endometriosis,
  • Severe male factor
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Please refer to this study by its identifier: NCT00436462

Unit of Human Reproduction, 1st Department of Obstetrics & Gynecology, AUTH, Papageorgiou Hospital
Thessaloniki, Greece, 56429
Sponsors and Collaborators
Aristotle University Of Thessaloniki
Study Director: Basil C Tarlatzis, MD,PhD Unit of Human Reproduction, 1st Department of Obst & Gyn, Aristotle University of Thessaloniki, Papageorgiou Hospital, Greece