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Cell Mediated Immunity and the Prediction of CMV Infection In Solid Organ Transplant Recipients

This study has been completed.
The Physicians' Services Incorporated Foundation
Information provided by:
University Health Network, Toronto Identifier:
First received: February 15, 2007
Last updated: April 15, 2008
Last verified: February 2007
Cytomegalovirus (CMV) is a common cause of illness in patients who have undergone a transplant. Serious infections due to CMV can affect many parts of the body including the lungs, the gut, and the liver. Since transplant recipients are at risk for CMV or have evidence of infection with CMV, they are given an antiviral drug (usually ganciclovir or valganciclovir). Despite this, there are a chance that CMV infection may cause problems in the future. The purpose of this study is to assess how well patients'immune systems responds to the CMV virus, so that in the future it may be possible to predict which patients are at highest risk of CMV.

Condition Intervention Phase
Procedure: Monitoring-blood samples drawn for CMV testing
Phase 4

Study Type: Observational
Official Title: Cell Mediated Immunity and the Prediction of CMV Infection In Solid Organ Transplant Recipients

Resource links provided by NLM:

Further study details as provided by University Health Network, Toronto:

Estimated Enrollment: 150
Study Start Date: November 2005
Study Completion Date: March 2008
Primary Completion Date: March 2008 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Male or female patients who fulfill the following criteria are eligible for inclusion.

    • CMV D+/R- liver, kidney and heart recipient
    • CMV R+ liver,kidney and heart recipients who have received thymoglobulin induction therapy.
    • D+/R- and R+ lung transplant recipients.
    • Able to give written informed consent
    • Are willing and able to comply with the protocol
    • Age >=18 years

Exclusion Criteria:

  • Patient unwilling or unable to give informed consent
  Contacts and Locations
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Please refer to this study by its identifier: NCT00436384

Canada, Ontario
University Health Network
Toronto, Ontario, Canada, M5G 2N2
Sponsors and Collaborators
University Health Network, Toronto
The Physicians' Services Incorporated Foundation
Principal Investigator: Atul Humar, MD University Health Network, Toronto
Principal Investigator: Deepali Kumar, MD University Health Network, Toronto
  More Information Identifier: NCT00436384     History of Changes
Other Study ID Numbers: 05-0265-AE
Study First Received: February 15, 2007
Last Updated: April 15, 2008

Keywords provided by University Health Network, Toronto:
liver transplant
lung transplant
kidney transplant
heart transplant

Additional relevant MeSH terms:
Cytomegalovirus Infections
Herpesviridae Infections
DNA Virus Infections
Virus Diseases processed this record on May 25, 2017