Safety and Efficacy Study of Glufosfamide in Patients With Recurrent Sensitive Small Cell Lung Carcinoma

This study has been terminated.
Information provided by:
Threshold Pharmaceuticals Identifier:
First received: February 13, 2007
Last updated: April 28, 2009
Last verified: April 2009

The primary objectives of this study are:

  1. To evaluate the efficacy of glufosfamide in subjects with extensive recurrent sensitive small cell lung cancer (SCLC) as measured by objective response rate
  2. To evaluate the safety of glufosfamide in subjects with extensive recurrent sensitive SCLC

The secondary objectives are:

  1. To evaluate the efficacy of glufosfamide in subjects with extensive recurrent sensitive SCLC as measured by duration of response, progression-free survival and overall survival
  2. To evaluate the pharmacokinetics of glufosfamide and isophosphoramide mustard (IPM)

The exploratory objectives of this trial are:

  1. To evaluate the effect of glufosfamide on lung cancer symptoms
  2. To evaluate the role of tumor cell glucose transporter expression on the efficacy of glufosfamide

Condition Intervention Phase
Carcinoma, Small Cell Lung
Drug: Glufosfamide
Phase 2

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: An Open-Label, Phase 2 Study to Evaluate the Safety and Efficacy of Glufosfamide in the Treatment of Patients With Recurrent Sensitive Small Cell Lung Carcinoma

Resource links provided by NLM:

Further study details as provided by Threshold Pharmaceuticals:

Estimated Enrollment: 50
Study Start Date: February 2007
Study Completion Date: November 2007
Primary Completion Date: November 2007 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • At least 18 years of age
  • Ability to understand the purposes and risks of the study and has signed a written informed consent form approved by the investigator's IRB/IEC
  • Documented extensive SCLC with progression occurring at least 60 days after completion of first-line therapy (sensitive disease)
  • Measurable disease by RECIST criteria (at least one target lesion; no target lesion may have received radiotherapy within 6 weeks of study start)
  • A minimum of 21 days between prior radiation therapy, immunotherapy, or other anti-tumor therapy and study entry
  • Recovered from reversible toxicities of prior therapy
  • Eastern Cooperative Oncology Group (ECOG) Performance Status score of 0, 1, or 2
  • Hemoglobin ≥ 9.0 g/dL, ANC ≥ 1,500/µL, platelets ≥ 100,000/µL
  • Total bilirubin ≤ 1.5-fold ULN
  • AST/ALT ≤ 2.5-fold ULN (≤ 5-fold ULN if liver metastases)
  • Creatinine clearance ≥ 60 mL/min (calculated by Cockcroft-Gault formula)
  • All women of childbearing potential and all men must agree to use effective means of contraception (surgical sterilization or the use of barrier contraception with either a condom or diaphragm in conjunction with spermicidal gel or an IUD) from entry into the study through 6 months after the last dose

Exclusion Criteria:

  • More than one previous chemotherapy regimen
  • Concomitant or planned hormonal therapy, radiation therapy, biologic therapy, chemotherapy or other systemic antitumor therapy for SCLC other than protocol therapy
  • Limited stage SCLC (defined as confined to one hemithorax including ipsilateral supraclavicular lymph nodes and excluding pleural effusion)
  • Symptomatic brain metastases requiring corticosteroids
  • Active clinically significant infection requiring antibiotics
  • Known HIV positive or active hepatitis B or C
  • Recent (one year) history or symptoms of cardiovascular disease (NYHA Class 2, 3, or 4), particularly coronary artery disease, arrhythmias or conduction defects with risk of cardiovascular instability, uncontrolled hypertension, clinically significant pericardial effusion, congestive heart failure, or stroke
  • Other active malignancies (other than treated non-melanoma skin cancer or treated in situ cancer) within the past 5 years
  • Major surgery within 28 days of the start of study treatment, without complete recovery
  • Females who are pregnant or breast-feeding
  • Participation in an investigational drug or device study within 28 days of the first day of dosing on this study
  • Concomitant disease or condition that could interfere with the conduct of the study, or that, in the opinion of the investigator, could pose an unacceptable risk to the subject in this study.
  • Unwillingness or inability to comply with the study protocol for any other reason
  Contacts and Locations
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Please refer to this study by its identifier: NCT00435578

United States, California
California Cancer Center
Greenbrae, California, United States, 94904
United States, Florida
H. Lee Moffitt Cancer Center and Research Institute
Tampa, Florida, United States, 33612
United States, Michigan
Karmanos Cancer Institute
Detroit, Michigan, United States, 48201
Sponsors and Collaborators
Threshold Pharmaceuticals
Principal Investigator: Gerold Bepler, MD, PhD H. Lee Moffitt Cancer Center and Research Institute
Principal Investigator: John C Ruckdeschel, MD Barbara Ann Karmanos Cancer Institute
Principal Investigator: Peter D Eisenberg, MD California Cancer Center
  More Information Identifier: NCT00435578     History of Changes
Other Study ID Numbers: TH-CR-304 
Study First Received: February 13, 2007
Last Updated: April 28, 2009
Health Authority: United States: Food and Drug Administration

Keywords provided by Threshold Pharmaceuticals:
Recurrent Sensitive Small-Cell Lung Cancer

Additional relevant MeSH terms:
Carcinoma, Small Cell
Lung Neoplasms
Small Cell Lung Carcinoma
Bronchial Neoplasms
Carcinoma, Bronchogenic
Lung Diseases
Neoplasms by Histologic Type
Neoplasms by Site
Neoplasms, Glandular and Epithelial
Respiratory Tract Diseases
Respiratory Tract Neoplasms
Thoracic Neoplasms processed this record on May 04, 2016