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Epstein-Barr Virus as a Possible Cause for Chronic Fatigue Syndrome
This study has been completed.
Sponsor:
University of Mississippi Medical Center
Collaborator:
Ohio State University
Information provided by:
University of Mississippi Medical Center
ClinicalTrials.gov Identifier:
NCT00433355
First received: February 7, 2007
Last updated: March 18, 2009
Last verified: March 2009
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Purpose
The purpose of this study is to understand what causes a continuing fatigue for a long time with a number of symptoms occurring at the same time (Chronic Fatigue Syndrome-CFS). Epstein Barr Virus is among the group of viruses that have been associated with a continuing fatigue for a long time with a number of symptoms occurring at the same time, but the cause is still unknown.
| Condition |
|---|
| Chronic Fatigue Syndrome |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Prospective |
| Official Title: | Studies on Epstein-Barr Virus as a Possible Etiological Agent for Chronic Fatigue Syndrome |
Resource links provided by NLM:
Further study details as provided by University of Mississippi Medical Center:
| Enrollment: | 15 |
| Study Start Date: | January 2007 |
| Study Completion Date: | October 2008 |
| Primary Completion Date: | August 2008 (Final data collection date for primary outcome measure) |
Epstein-Barr virus (EBV) is the etiological agent for heterophile positive infectious mononucleosis (IM). It is also an oncogenic herpes virus associated with African Burkitt's lymphoma (BL),nasopharyngeal carcinoma (NPC) and AIDS-associated B-cell lymphomas. EBV is also among a group of viruses that have been associated with chronic fatigue syndrome (CFS), although the etiology of CFS still remains unknown.Findings may lead to hypothesize that EBV enzymes, such as the dUTPase, have the capacity to induce immune dysregulation of the T-cell and NK cell responses and that this immune dysregulation produces immunopathology that results in the symptoms that we call CFS.
Eligibility| Ages Eligible for Study: | 18 Years and older (Adult, Senior) |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Study Population
18 y/o and above with history of CFS matched those without as to age and gender.
Criteria
Inclusion Criteria:
- Healthy adults for controls.
- Adults with chronic fatigue syndrome.
Exclusion Criteria:
- Individuals with significant medical illness in reference to immunosuppressant drug.
Note: We recruit participants in the Mississippi area who could come in our site to provide blood draw.
Contacts and Locations
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To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00433355
Please refer to this study by its ClinicalTrials.gov identifier: NCT00433355
Locations
| United States, Mississippi | |
| University of Mississippi Medical Center | |
| Jackson, Mississippi, United States, 39216-4505 | |
Sponsors and Collaborators
University of Mississippi Medical Center
Ohio State University
Investigators
| Principal Investigator: | Gailen D Marshall, M.D., PhD | University of Mississippi Medical Center |
More Information
| Responsible Party: | Gailen D. Marshall, MD, PhD, The University of Mississippi Medical Center |
| ClinicalTrials.gov Identifier: | NCT00433355 History of Changes |
| Other Study ID Numbers: |
2006-0265 |
| Study First Received: | February 7, 2007 |
| Last Updated: | March 18, 2009 |
Keywords provided by University of Mississippi Medical Center:
|
Chronic Fatigue Syndrome Epstein-Barr Virus |
Additional relevant MeSH terms:
|
Syndrome Fatigue Fatigue Syndrome, Chronic Disease Pathologic Processes Signs and Symptoms Virus Diseases |
Muscular Diseases Musculoskeletal Diseases Encephalomyelitis Central Nervous System Diseases Nervous System Diseases Neuromuscular Diseases |
ClinicalTrials.gov processed this record on July 14, 2017