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Epstein-Barr Virus as a Possible Cause for Chronic Fatigue Syndrome

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00433355
First Posted: February 9, 2007
Last Update Posted: March 19, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Ohio State University
Information provided by:
University of Mississippi Medical Center
  Purpose
The purpose of this study is to understand what causes a continuing fatigue for a long time with a number of symptoms occurring at the same time (Chronic Fatigue Syndrome-CFS). Epstein Barr Virus is among the group of viruses that have been associated with a continuing fatigue for a long time with a number of symptoms occurring at the same time, but the cause is still unknown.

Condition
Chronic Fatigue Syndrome

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Studies on Epstein-Barr Virus as a Possible Etiological Agent for Chronic Fatigue Syndrome

Resource links provided by NLM:


Further study details as provided by University of Mississippi Medical Center:

Enrollment: 15
Study Start Date: January 2007
Study Completion Date: October 2008
Primary Completion Date: August 2008 (Final data collection date for primary outcome measure)
Detailed Description:
Epstein-Barr virus (EBV) is the etiological agent for heterophile positive infectious mononucleosis (IM). It is also an oncogenic herpes virus associated with African Burkitt's lymphoma (BL),nasopharyngeal carcinoma (NPC) and AIDS-associated B-cell lymphomas. EBV is also among a group of viruses that have been associated with chronic fatigue syndrome (CFS), although the etiology of CFS still remains unknown.Findings may lead to hypothesize that EBV enzymes, such as the dUTPase, have the capacity to induce immune dysregulation of the T-cell and NK cell responses and that this immune dysregulation produces immunopathology that results in the symptoms that we call CFS.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
18 y/o and above with history of CFS matched those without as to age and gender.
Criteria

Inclusion Criteria:

  • Healthy adults for controls.
  • Adults with chronic fatigue syndrome.

Exclusion Criteria:

  • Individuals with significant medical illness in reference to immunosuppressant drug.

Note: We recruit participants in the Mississippi area who could come in our site to provide blood draw.

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00433355


Locations
United States, Mississippi
University of Mississippi Medical Center
Jackson, Mississippi, United States, 39216-4505
Sponsors and Collaborators
University of Mississippi Medical Center
Ohio State University
Investigators
Principal Investigator: Gailen D Marshall, M.D., PhD University of Mississippi Medical Center
  More Information

Responsible Party: Gailen D. Marshall, MD, PhD, The University of Mississippi Medical Center
ClinicalTrials.gov Identifier: NCT00433355     History of Changes
Other Study ID Numbers: 2006-0265
First Submitted: February 7, 2007
First Posted: February 9, 2007
Last Update Posted: March 19, 2009
Last Verified: March 2009

Keywords provided by University of Mississippi Medical Center:
Chronic Fatigue Syndrome
Epstein-Barr Virus

Additional relevant MeSH terms:
Syndrome
Fatigue
Fatigue Syndrome, Chronic
Disease
Pathologic Processes
Signs and Symptoms
Virus Diseases
Muscular Diseases
Musculoskeletal Diseases
Encephalomyelitis
Central Nervous System Diseases
Nervous System Diseases
Neuromuscular Diseases