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Correlation Between Coital Activity During Pregnancy and Premature Delivery Related to Prostanoid Receptor Polymorphisms

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified February 2007 by Shaare Zedek Medical Center.
Recruitment status was:  Not yet recruiting
Information provided by:
Shaare Zedek Medical Center Identifier:
First received: February 8, 2007
Last updated: NA
Last verified: February 2007
History: No changes posted
The purpose of our study is correlate between premature delivery (between week 23-35 of the pregnancy) in women that had intercourse up to 12 hours prior to beginning of labor and polymorphisms in the gene Prostanoid receptor.

Condition Intervention
Labor Onset Gravidity Behavioral: Correlation between early delivery and coital activity

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Correlation Between Coital Activity During Pregnancy and Premature Delivery Related to Prostanoid Receptor Polymorphisms

Further study details as provided by Shaare Zedek Medical Center:

Detailed Description:

During the past years there has been a conflict between different studies regarding the correlation between intercourse during pregnancy and early labor. Brustman et al showed that women that were at a high risk for early delivery and had intercourse and then an early labor had significantly increase uterine activity compared to women at low risk. Petridou et al showed that this risk is significantly higher at week 33 of gestation. However, the Cochrane Library summary leaves the question of correlation between intercourse and early labor unanswered. In Sayle et al's study showed no correlation between early delivery and intercourse. In 2004 Oguma described 3 polymorphisms in the Prostanoid receptor gene. These polymorphisms were correlated to increased activity of smooth muscles of bronchi in asthma. Since this gene is also expressed in the uterine muscles we wanted to determine whether there is a correlation between the three polymorphisms T-549C, C-441T, T-197C, G+1044A and early delivery due to intercourse.

  1. Brustman LS, Raptoulis M. Langer O, Anyaegbunam A & Merkatz IR. Changes in the pattern of uterine contractility in relationship to coitus during pregnancies at low and high risk for preterm labor. Obstet Gynecol 1989;73:166-168
  2. Petridou E, Salvnos H, Skalkidou A, Dessypris N, Moustaki M & Trichopoulos D. Are there common triggers of preterm deliveries. British J Obst Gynecol 2001;108:598-604)
  3. Kavanagh J, Kelly AJ & Thomas J. Sexual intercourse for cervical ripening and induction of labour. The Cochrane Database of Systematic Reviews 2001, Issuse 2.Art. No.:CD003093. DOI: 10.1002/14651858.CD003093
  4. Sayle AE, Savitz DA, Thorp JM, Hertz-Picciotto I & Wilcox AJ. Sexual activity during late pregnancy and risk of preterm delivery. Obstet Gynecol 2001;97:283-9)
  5. Bernal AL. Mechanisms of labour-biochemical aspects. BJOG 2003;110(Supp 20):39-45
  6. Oguma T, Palmer L, Birden E, Sonna LA, Asano K& Lilly CM. Role of prostanoid dp receptor variants in susceptibility to asthma. NEJM 2004;351:1752-63

Ages Eligible for Study:   20 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Female

Inclusion Criteria:

  • Women who start delivery in weeks 23-35 of pregnancy 12 hours after intercourese.
  • Women who come for delivery after week 31 and have not had intercourse during the previous month.
  • Women at term who have been sexually active during their pregnancy.

Exclusion Criteria:

  • Any other women who come in for delivery.
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Please refer to this study by its identifier: NCT00433303

Contact: Michael Schimmel, Prof. 972-2-6550689

Shaare Zedek Medical Center
Jerusalem, Israel, 91031
Sponsors and Collaborators
Shaare Zedek Medical Center
Principal Investigator: Michael Schimmel, Prof. Neonatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel
  More Information

Publications: Identifier: NCT00433303     History of Changes
Other Study ID Numbers: Intercourse-Prostanoid DP
Study First Received: February 8, 2007
Last Updated: February 8, 2007

Additional relevant MeSH terms:
Premature Birth
Obstetric Labor, Premature
Obstetric Labor Complications
Pregnancy Complications processed this record on September 19, 2017