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The Interrelation of the Vasculature, Endothelium, Bone Metabolism and Uremic Toxins in Peritoneal Dialysis (INVEST-PD)

This study has been completed.
Information provided by:
Universitaire Ziekenhuizen Leuven Identifier:
First received: February 7, 2007
Last updated: March 4, 2009
Last verified: March 2009

Despite major advances in the treatment of chronic kidney disease, the age and sex matched mortality far exceeds that of the normal population. As in the normal population, the majority of deaths are related to cardiovascular disease. Mounting data point to the lethal synergy between chronic kidney disease and cardiovascular disease. This relation is present from early stages of chronic kidney disease on.

Several uremic toxins have been demonstrated to play an important role in kidney disease related endothelial dysfunction. In peritoneal dialysis patients, data on the relation between uremic toxins, endothelial dysfunction and microparticles are lacking.

The investigators hypothesize that endothelial dysfunction and uremic toxins are interrelated in peritoneal dialysis patients

Condition Intervention Phase
Chronic Kidney Disease
Procedure: peritoneal dialysis
Early Phase 1

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: The Interrelation of the Vasculature, Endothelium, Bone Metabolism and Uremic Toxins in Peritoneal Dialysis

Resource links provided by NLM:

Further study details as provided by Universitaire Ziekenhuizen Leuven:

Biospecimen Retention:   Samples With DNA
serum, plasma, DNA

Enrollment: 62
Study Start Date: February 2007
Study Completion Date: December 2008
Primary Completion Date: December 2008 (Final data collection date for primary outcome measure)
Intervention Details:
    Procedure: peritoneal dialysis
    Other Name: individualised

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Tertiary referral center university hospital

Inclusion Criteria:

  • age > 18
  • Maintenance peritoneal dialysis

Exclusion Criteria:

  • No informed consent
  • Peritonitis
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Please refer to this study by its identifier: NCT00433264

Universitaire Ziekenhuizen Leuven
Leuven, Vlaams-Brabant, Belgium, 3000
Sponsors and Collaborators
Universitaire Ziekenhuizen Leuven
Principal Investigator: Bjorn Meijers, MD UZ Leuven
Principal Investigator: Kathleen Claes, MD UZ Leuven
Study Director: Pieter Evenepoel, MD, PhD UZ Leuven
  More Information

Responsible Party: Pieter Evenepoel, University Hospitals Leuven Identifier: NCT00433264     History of Changes
Other Study ID Numbers: ML3645
Study First Received: February 7, 2007
Last Updated: March 4, 2009

Keywords provided by Universitaire Ziekenhuizen Leuven:
peritoneal dialysis
endothelial dysfunction

Additional relevant MeSH terms:
Renal Insufficiency, Chronic
Kidney Diseases
Renal Insufficiency
Urologic Diseases processed this record on May 25, 2017