Study Concerning Relationship Between Mixed Venous Saturation (SvO2) and Balance

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00431535
Recruitment Status : Completed
First Posted : February 6, 2007
Last Update Posted : June 17, 2013
Information provided by:
Rigshospitalet, Denmark

Brief Summary:
It is the purpose of the investigators to investigate the possible relationship between fall in the amount of Oxygen in the blood and disturbances of balance-function before and after surgery.

Condition or disease

Detailed Description:

It has been shown that the mixed venous saturation (SvO2) is usable as a parameter of fluid status. It has also been suggested that there is a connection between SvO2 and blood flow in tissue , and that a SvO2 of less than 40% is a sign of tissue hypoxia.

Recently it has been shown that patients going through heart surgery experience a drop in SvO2 during early mobilization.This drop lasts throughout the mobilisation process.

We want to investigate whether the same mechanism applies to patients going through other types of surgery, and whether there is a connection between a drop in SvO2 and orthostatic function.

This will be done by making 3 tests. One pre-operatively,one six hours post-operatively and one 18-24 hours after surgery.

The tests will consist of:

  1. 10 min of rest.
  2. 3 min of sitting upright on the side of the bed. C. 3 min of standing on the floor. D. 10 min of rest.

Between each position a venous blood sample will be taken. Also 1 blood sample will be taken at the end of surgery.

Continuous measurements by the Finapres system wil be made throughout the test-sequence to investigate changes in BP, SV, TPR and HR.

At the same time the patient will be pain-scored when taking a new position.

Study Type : Observational
Actual Enrollment : 17 participants
Time Perspective: Prospective
Official Title: Descriptive Study Concerning the Connection Between SvO2 and Orthostatic Function Post Operatively
Study Start Date : February 2007
Actual Study Completion Date : May 2007

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients going through Radical Prostatectomy, where CVC is standard.

Exclusion Criteria:

  • Non informed consent
  • ASA > II
  • Age less than 18, or more than 80 years
  • Diabetes Mellitus
  • Epidural analgetics
  • Alcohol abuse (investigators assessment)
  • Unable to understand written or spoken information
  • Using beta-blockers

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00431535

Dept of anesthesia 2041, ABD centre, Rigshospitalet, Blegdamsvej
Copenhagen, Seeland, Denmark, 2200
Copenhagen, Seeland, Denmark, 2200
Sponsors and Collaborators
Rigshospitalet, Denmark
Principal Investigator: Christoffer Joergensen, M.S. Identifier: NCT00431535     History of Changes
Other Study ID Numbers: SvO2
First Posted: February 6, 2007    Key Record Dates
Last Update Posted: June 17, 2013
Last Verified: October 2007

Keywords provided by Rigshospitalet, Denmark:
Orthostatic function