Cardiovascular Outcomes in the VA's Rheumatoid Arthritis(VARA) Population
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|ClinicalTrials.gov Identifier: NCT00431405|
Recruitment Status : Unknown
Verified February 2007 by Dallas VA Medical Center.
Recruitment status was: Active, not recruiting
First Posted : February 5, 2007
Last Update Posted : February 5, 2007
Rheumatoid arthritis (RA) is a symmetric, peripheral polyarthritis of uncertain etiology that can lead to joint deformity and destruction. However, the effects of RA are not confined simply to joint involvement. Virtually every organ system can be affected by RA if left untreated. Of particular note is RA’s affect on the cardiovascular system. RA patients have a reduced lifespan compared to the general population primarily due to an increased cardiovascular disease burden (1). Recently, RA has been linked to the development of preclinical atherosclerosis in the carotid arteries as measured by ultrasonography (2). Women with RA have also been shown to have an increased incidence of nonfatal myocardial infarctions (3). Despite these studies showing the effects of RA on the cardiovascular disease burden of those who are afflicted, no study to date has compared the number of cardiovascular events in a large RA patient population to a risk factor and age matched control group. Consequently it is the goal of this study to determine whether the cardiovascular event ratio in an RA patient cohort exceeds an age and risk factor matched cohort of non-RA patients. This study will also attempt to ascertain whether specific cardiovascular risk factors contribute to the cardiovascular morbidity and mortality associated with RA and if any standard cardiovascular medicines disproportionately contribute to patient outcome.
Hypothesis: Given the increased cardiovascular disease burden associated with RA patients they are likely to suffer from a statistically significant increased risk of cardiovascular events when compared to an age and risk factor matched cohort.
|Condition or disease|
|Rheumatoid Arthritis Cardiovascular Disease Coronary Disease|
|Study Type :||Observational|
|Enrollment :||450 participants|
|Observational Model:||Defined Population|
|Observational Model:||Natural History|
|Official Title:||Assessing Risk of Cardiovascular Events in RA Patients Using a Retrospective Cohort From the VARA Registry|
|Study Start Date :||August 2006|
|Study Completion Date :||January 2007|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00431405
|United States, Texas|
|Dallas VA Medical Center-Rheumatology|
|Dallas, Texas, United States, 75216|
|Principal Investigator:||Salahuddin Kazi, MBBS||Dallas VA Medical Center|