The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
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Cortico-dependence is frequent in giant cell arteritis patients, and no drugs has proved its ability to prevent corticodependence. Hydrocychloroquine is a well tolerated immunomodulatory drug that may have a corticosteroid sparing potential according to immuno-pharmacological and clinical data. We have designed a multcentric double blind versus placebo randomized controled trial to assess the corticosteroid sparing effect of hydroxychloroquine in non complicated giant cell arteritis.
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Ages Eligible for Study:
18 Years to 85 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
giant celle arteritis with at least 3 ACR criteria including a disgnostic temporal artery biopsy
corticosteroid treatment since less than 1 month
age less than 85 years
signed informed consent
amaurosis fugax, loss of vision, acute lumb ischemia, angina pectoris or myocardium infarctus, mesenteric ischemia or other vascular complications related to GCA
low life expectancy (<2 years)
corticosteroid treatment since more than 30 days whatever the dosage
primary corticosteroid resistance defined by persistant symptoms despite prednisone for more than 15 days
Arteritis Giant Cell Arteritis
Vasculitis, Central Nervous System
Autoimmune Diseases of the Nervous System
Nervous System Diseases
Central Nervous System Diseases
Skin Diseases, Vascular