Double Blind Crossover Comparison of Diuretics in the Young
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|ClinicalTrials.gov Identifier: NCT00429897|
Recruitment Status : Unknown
Verified January 2007 by University of Cambridge.
Recruitment status was: Recruiting
First Posted : February 1, 2007
Last Update Posted : February 1, 2007
The principle objective of the study is to determine whether low-renin (i.e. salt sensitive) hypertension at a young age is caused by the kidneys hanging onto too much salt as a result of an over active salt pump in the kidney.
The kidneys have four different salt pumps, and each is blocked by a different type of diuretic (salt losing tablet)If one out of the four is overactive, we would expect patients to respond much better to one diuretic than to the alternatives - rather than responding equally well to all available types of diuretic.
|Condition or disease||Intervention/treatment||Phase|
|Low-Renin Hypertension||Drug: Bendroflumethiazide 2.5mg - 5mg Drug: Amiloride 20-40mg Drug: Spironolactone 50-100mg Drug: Frusemide 20-40mg Drug: Bendroflumethiazide 1.25-2.5mg/ Amiloride 10-20mg combined||Not Applicable|
Studies suggest that patients with low renin hypertension respond better to diuretics than other hypertensive drug groups. The aim of the study is to rotate patients through the four main diuretic groups and see if it is possible to identify the most effective diuretic for this group, as measured by a >=10mgHg decrease in Systolic blood pressure in one specific group a compared to the others.
As most caucasians with Low renin hypertension are older (>55), presentation with this type of hypertension at a younger age suggests the presence of substantial genetic variation in order to cause the atypical presentation. It is hoped that by identifying the best diuretic for these patients we will also be able to identify:
- Whether the young low-renin hypertensives can be sub-classified according to their most effective diuretic;
- Whether this sub-classification helps us to identify the genes and mutations responsible, since these are to expected to be in the so-called sodium channels (i.e. salt pumps)which the kidneys use to prevent salt being excreted in the urine.
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||30 participants|
|Intervention Model:||Crossover Assignment|
|Official Title:||Double Blind Crossover Comparison od Diuretics in Young Patients With Low Renin Hypertension|
|Study Start Date :||August 2006|
|Study Completion Date :||July 2007|
- Difference in systolic blood pressure for subjects' best drug and second best drug.
- Difference in plasma renin for subjects' best drug and second best drug.
- Predictions of best drug
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00429897
|Contact: Morris J Brown, Professor||01223 firstname.lastname@example.org|
|University of Cambridge - Addenbrookes Hospital||Recruiting|
|Cambridge, United Kingdom, CB2 2QQ|
|Contact: Morris J Brown, Proffessor 01223 336743 email@example.com|
|Sub-Investigator: Sue Hood, RGN - sister|
|Sub-Investigator: Diane Picton, RGN- sister|
|Sub-Investigator: Tim Burton, Phd, MRCP|
|Principal Investigator:||Morris J Brown, Proffessor||Cambridge University|