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Hormonal Levels in Men With Major Depressive Disorder

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ClinicalTrials.gov Identifier: NCT00429689
Recruitment Status : Withdrawn
First Posted : February 1, 2007
Last Update Posted : August 30, 2011
Information provided by:
Sheba Medical Center

Brief Summary:

Subjects will be 1000 men meeting the following inclusion criteria: 1) male, age 18-65 years; 2) meeting DSM-IV criteria for major depressive disorder within the past one year, with a HAM-D score >12.

Subjects will be excluded if they exhibit 1) a substance abuse or dependence disorder within the past year; 2) current psychotic symptoms; or 3) a history of bipolar disorder.


After informed consent, eligible patients will have blood drawn for serum hormone levels; cortisol, DHEA-S and testosterone or they will provide a salivary sample for measurement of hormone levels.

We will also test hormone level form 1000 healthy males (from blood or saliva) at the same age for comparison.

Condition or disease Intervention/treatment
Depression Procedure: Saliva sample

Study Type : Observational
Estimated Enrollment : 2000 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Hormonal Levels in Men With Major Depressive Disorder

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Men diagnosed with Major depression disorder

Inclusion Criteria:

  • Male
  • Major Depression Disorder
  • 18-65

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00429689

Sponsors and Collaborators
Sheba Medical Center
Study Director: Stuart Seidman,, MD West End Medical Associates
Principal Investigator: Revital Amiaz, MD Sheba Medical Center

Responsible Party: Amiaz Revital, MD, Sheba Medical Center
ClinicalTrials.gov Identifier: NCT00429689     History of Changes
Other Study ID Numbers: SHEBA-06-4480-RA-CTIL
First Posted: February 1, 2007    Key Record Dates
Last Update Posted: August 30, 2011
Last Verified: August 2011

Keywords provided by Sheba Medical Center:
Male, MDD, Testosterone, DHEA-S,Cortisol
Major Depression

Additional relevant MeSH terms:
Depressive Disorder
Depressive Disorder, Major
Behavioral Symptoms
Mood Disorders
Mental Disorders