Noninvasive Ventilatory Support After Lung Surgery in COPD Patients (POPVNI)
|ClinicalTrials.gov Identifier: NCT00428857|
Recruitment Status : Completed
First Posted : January 30, 2007
Last Update Posted : February 24, 2011
Rationale: respiratory complications are the most frequent complications following lung resection and represent a noticeable cause of mortality. Benefits from non-invasive ventilation (NIV) in acute respiratory failure are now clearly demonstrated. The use of preventive NIV after lung resection, in the absence of acute respiratory failure and/or hypercarbia, could be justified by the physiological benefits expected. The goal of this study is to assess the efficacy of post-operative NIV in moderate-to-severe COPD, for prevention of respiratory complications.
Material and Methods: This is a prospective randomised multicenter trial with an open parallel design in moderate-t-o-severe COPD patients hospitalised in thoracic surgery for lung resection.
Expected results: This study will determine whether post-operative NIV decreases the incidence of acute respiratory events (acute respiratory failure) and whether some subgroups of patients benefit more from this strategy.
Conclusion: This study should help evaluating the utility of post-operative NIV after lung resection.
|Condition or disease||Intervention/treatment|
|COPD Post Pulmonary Resection||Procedure: non invasive ventilation|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||360 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Noninvasive Ventilatory Support After Lung Surgery to Prevent Pulmonary Complications in COPD Patients|
|Study Start Date :||June 2008|
|Primary Completion Date :||October 2010|
|Study Completion Date :||October 2010|
Procedure: non invasive ventilation
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00428857
|Hopital Du Bocage|
|Dijon, France, 21034|
|Paris, France, 75004|
|Institut Mutualiste Montsouris|
|Paris, France, 75014|
|Paris, France, 75015|
|hopital de Pontoise|
|Toulouse, France, 31049|
|Principal Investigator:||christine lorut, MD||APHP|
|Principal Investigator:||antoine rabbat, MD||APHP|