Imatinib Mesylate Treatment of Patients With Malignant Peripheral Nerve Sheath Tumors
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ClinicalTrials.gov Identifier: NCT00427583
(stopped due to slow recruitment and no effect)
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients ≥18 years of age
Histologically documented diagnosis of malignant MPNST
Unresectable local MPNST or metastatic MPNST and therefore incurable with any conventional multimodality approach Life expectancy of at least 6 months.
Patient has received any other investigational agents within 28 days of first day of study drug dosing.
Chemotherapy and or radiotherapy in between the last 6 weeks before study entry, surgery in between the last 14 days before study entry.
Female patients who are pregnant or breast feeding or women of child bearing potential who are not using a highly effective method of birth control.
Known CNS metastases
Other protocol-defined inclusion/exclusion criteria may apply.