Effect of Postoperative Laxative on Bowel Function After Colonic Surgery

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00427492
Recruitment Status : Completed
First Posted : January 29, 2007
Last Update Posted : February 11, 2009
Information provided by:
Hvidovre University Hospital

Brief Summary:
Randomised doublet blinded study of the effect of tablet Magnesia (laxative) on post operative bowel ileus after open colonic resection. Material: 56 patients in two equal groups. Primary endpoint: Bowel function. Secondary endpoints: Intake of food and drinks.

Condition or disease Intervention/treatment Phase
Colonic Cancer Drug: Magnesia Drug: Placebo Phase 4

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 56 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Supportive Care
Official Title: Effect of Postoperative Laxative on Bowel Function After Colonic Surgery
Study Start Date : January 2007
Actual Primary Completion Date : January 2009
Actual Study Completion Date : January 2009

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Bowel Movement
U.S. FDA Resources

Arm Intervention/treatment
Active Comparator: Magnesia
Medical laxative
Drug: Magnesia
Tablet magnesia 500mg. 2 tablet 2 times a day for a week
Drug: Placebo
Placebo Comparator: Placebo
Drug: Placebo

Primary Outcome Measures :
  1. Time to defecation after colonic resection [ Time Frame: 2-8 days ]

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All

Inclusion Criteria:

  • Patients with planned elective colonic resection

Exclusion Criteria:

  • Previous extended abdominal surgery
  • Pregnancy
  • Opioid or alcohol abuse

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00427492

Copenhagen University hospital Hvidovre
Hvidovre, Denmark, 2650
Sponsors and Collaborators
Hvidovre University Hospital
Principal Investigator: Jens Andersen, MD Copenhagen University Hospital, Hvidovre

Responsible Party: Jens Andersen. Consultant Surgeon, Copenhagen University Hospital - Hvidovre Identifier: NCT00427492     History of Changes
Other Study ID Numbers: 02 290964
First Posted: January 29, 2007    Key Record Dates
Last Update Posted: February 11, 2009
Last Verified: February 2009

Additional relevant MeSH terms:
Colonic Neoplasms
Colorectal Neoplasms
Intestinal Neoplasms
Gastrointestinal Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Digestive System Diseases
Gastrointestinal Diseases
Colonic Diseases
Intestinal Diseases
Magnesium Oxide
Gastrointestinal Agents
Molecular Mechanisms of Pharmacological Action