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Effect of Postoperative Laxative on Bowel Function After Colonic Surgery

This study has been completed.
Information provided by:
Hvidovre University Hospital Identifier:
First received: January 26, 2007
Last updated: February 10, 2009
Last verified: February 2009
Randomised doublet blinded study of the effect of tablet Magnesia (laxative) on post operative bowel ileus after open colonic resection. Material: 56 patients in two equal groups. Primary endpoint: Bowel function. Secondary endpoints: Intake of food and drinks.

Condition Intervention Phase
Colonic Cancer Drug: Magnesia Drug: Placebo Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Supportive Care
Official Title: Effect of Postoperative Laxative on Bowel Function After Colonic Surgery

Resource links provided by NLM:

Further study details as provided by Hvidovre University Hospital:

Primary Outcome Measures:
  • Time to defecation after colonic resection [ Time Frame: 2-8 days ]

Enrollment: 56
Study Start Date: January 2007
Study Completion Date: January 2009
Primary Completion Date: January 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Magnesia
Medical laxative
Drug: Magnesia
Tablet magnesia 500mg. 2 tablet 2 times a day for a week
Drug: Placebo
Placebo Comparator: Placebo
Drug: Placebo


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All

Inclusion Criteria:

  • Patients with planned elective colonic resection

Exclusion Criteria:

  • Previous extended abdominal surgery
  • Pregnancy
  • Opioid or alcohol abuse
  Contacts and Locations
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Please refer to this study by its identifier: NCT00427492

Copenhagen University hospital Hvidovre
Hvidovre, Denmark, 2650
Sponsors and Collaborators
Hvidovre University Hospital
Principal Investigator: Jens Andersen, MD Copenhagen University Hospital, Hvidovre
  More Information

Responsible Party: Jens Andersen. Consultant Surgeon, Copenhagen University Hospital - Hvidovre Identifier: NCT00427492     History of Changes
Other Study ID Numbers: 02 290964
Study First Received: January 26, 2007
Last Updated: February 10, 2009

Additional relevant MeSH terms:
Colonic Neoplasms
Colorectal Neoplasms
Intestinal Neoplasms
Gastrointestinal Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Digestive System Diseases
Gastrointestinal Diseases
Colonic Diseases
Intestinal Diseases
Magnesium Oxide
Gastrointestinal Agents
Molecular Mechanisms of Pharmacological Action processed this record on August 18, 2017