Effect of Postoperative Laxative on Bowel Function After Colonic Surgery

This study has been completed.
Information provided by:
Hvidovre University Hospital
ClinicalTrials.gov Identifier:
First received: January 26, 2007
Last updated: February 10, 2009
Last verified: February 2009
Randomised doublet blinded study of the effect of tablet Magnesia (laxative) on post operative bowel ileus after open colonic resection. Material: 56 patients in two equal groups. Primary endpoint: Bowel function. Secondary endpoints: Intake of food and drinks.

Condition Intervention Phase
Colonic Cancer
Drug: Magnesia
Drug: Placebo
Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Supportive Care
Official Title: Effect of Postoperative Laxative on Bowel Function After Colonic Surgery

Resource links provided by NLM:

Further study details as provided by Hvidovre University Hospital:

Primary Outcome Measures:
  • Time to defecation after colonic resection [ Time Frame: 2-8 days ] [ Designated as safety issue: Yes ]

Enrollment: 56
Study Start Date: January 2007
Study Completion Date: January 2009
Primary Completion Date: January 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Magnesia
Medical laxative
Drug: Magnesia
Tablet magnesia 500mg. 2 tablet 2 times a day for a week
Drug: Placebo
Placebo Comparator: Placebo
Drug: Placebo


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both

Inclusion Criteria:

  • Patients with planned elective colonic resection

Exclusion Criteria:

  • Previous extended abdominal surgery
  • Pregnancy
  • Opioid or alcohol abuse
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00427492

Copenhagen University hospital Hvidovre
Hvidovre, Denmark, 2650
Sponsors and Collaborators
Hvidovre University Hospital
Principal Investigator: Jens Andersen, MD Copenhagen University Hospital, Hvidovre
  More Information

Responsible Party: Jens Andersen. Consultant Surgeon, Copenhagen University Hospital - Hvidovre
ClinicalTrials.gov Identifier: NCT00427492     History of Changes
Other Study ID Numbers: 02 290964 
Study First Received: January 26, 2007
Last Updated: February 10, 2009
Health Authority: Denmark: Danish Medicines Agency

Additional relevant MeSH terms:
Gastrointestinal Agents
Pharmacologic Actions
Therapeutic Uses

ClinicalTrials.gov processed this record on May 03, 2016