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Heredity of Retinal Vessel Tortuosity

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00427063
First Posted: January 26, 2007
Last Update Posted: January 26, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Juvenile Diabetes Research Foundation
Information provided by:
Glostrup University Hospital, Copenhagen
  Purpose
The purpose of this study is to asses the relative influence of genetic and environmental influence on the tortuosity of retinal arterioles in eyes of 218 healthy Danish twins aged 20-46 years. We expect to find a high heredity for the variation in tortuosity. This knowledge can contribute to the elucidation of the pathology in retinal diseases.

Condition
Retinopathy of Prematurity

Study Type: Observational
Study Design: Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: Heredity of Retinal Vessel Tortuosity - A Twin Study

Resource links provided by NLM:


Further study details as provided by Glostrup University Hospital, Copenhagen:

Estimated Enrollment: 218
Study Start Date: January 1998
Estimated Study Completion Date: December 1998
Detailed Description:
All persons underwent an ophthalmic examination including refraction, slit lamp biomicroscopy and digital fundus photography. Two independent graders (both with an MD degree) made a visual grading of the severity of tortuosity of the retinal arterioles in the fundus images.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 46 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Samesex twin pairs of self-assessed good health

Exclusion Criteria:

  • Diabetes mellitus
  • Hypertension
  • Thyroid disease
  • Cataract or other opacities of the refractive media
  • Missing fundus photographs
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00427063


Locations
Denmark
Department of Ophthalmology Glostrup Hospital
Glostrup, Copenhagen County, Denmark, DK-2600
Sponsors and Collaborators
Glostrup University Hospital, Copenhagen
Juvenile Diabetes Research Foundation
Investigators
Principal Investigator: Michael Larsen, Prof. MD Department of Ophthalmology Glostrup Hospital University of Copenhagen
  More Information

ClinicalTrials.gov Identifier: NCT00427063     History of Changes
Other Study ID Numbers: Danish Twin Registry 1998
First Submitted: January 25, 2007
First Posted: January 26, 2007
Last Update Posted: January 26, 2007
Last Verified: January 2007

Keywords provided by Glostrup University Hospital, Copenhagen:
retinal vessels
tortuosity

Additional relevant MeSH terms:
Retinopathy of Prematurity
Retinal Diseases
Eye Diseases
Infant, Premature, Diseases
Infant, Newborn, Diseases
Glucuronyl glucosamine glycan sulfate
Anticoagulants
Hypolipidemic Agents
Antimetabolites
Molecular Mechanisms of Pharmacological Action
Lipid Regulating Agents
Fibrinolytic Agents
Fibrin Modulating Agents
Hypoglycemic Agents
Physiological Effects of Drugs