Heredity of Retinal Vessel Tortuosity

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00427063
Recruitment Status : Completed
First Posted : January 26, 2007
Last Update Posted : January 26, 2007
Juvenile Diabetes Research Foundation
Information provided by:
Glostrup University Hospital, Copenhagen

Brief Summary:
The purpose of this study is to asses the relative influence of genetic and environmental influence on the tortuosity of retinal arterioles in eyes of 218 healthy Danish twins aged 20-46 years. We expect to find a high heredity for the variation in tortuosity. This knowledge can contribute to the elucidation of the pathology in retinal diseases.

Condition or disease
Retinopathy of Prematurity

Detailed Description:
All persons underwent an ophthalmic examination including refraction, slit lamp biomicroscopy and digital fundus photography. Two independent graders (both with an MD degree) made a visual grading of the severity of tortuosity of the retinal arterioles in the fundus images.

Study Type : Observational
Enrollment : 218 participants
Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: Heredity of Retinal Vessel Tortuosity - A Twin Study
Study Start Date : January 1998
Study Completion Date : December 1998

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Ages Eligible for Study:   20 Years to 46 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Samesex twin pairs of self-assessed good health

Exclusion Criteria:

  • Diabetes mellitus
  • Hypertension
  • Thyroid disease
  • Cataract or other opacities of the refractive media
  • Missing fundus photographs

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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00427063

Department of Ophthalmology Glostrup Hospital
Glostrup, Copenhagen County, Denmark, DK-2600
Sponsors and Collaborators
Glostrup University Hospital, Copenhagen
Juvenile Diabetes Research Foundation
Principal Investigator: Michael Larsen, Prof. MD Department of Ophthalmology Glostrup Hospital University of Copenhagen Identifier: NCT00427063     History of Changes
Other Study ID Numbers: Danish Twin Registry 1998
First Posted: January 26, 2007    Key Record Dates
Last Update Posted: January 26, 2007
Last Verified: January 2007

Keywords provided by Glostrup University Hospital, Copenhagen:
retinal vessels

Additional relevant MeSH terms:
Retinopathy of Prematurity
Retinal Diseases
Eye Diseases
Infant, Premature, Diseases
Infant, Newborn, Diseases
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