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Heredity of Retinal Vessel Tortuosity

This study has been completed.
Juvenile Diabetes Research Foundation
Information provided by:
Glostrup University Hospital, Copenhagen Identifier:
First received: January 25, 2007
Last updated: NA
Last verified: January 2007
History: No changes posted
The purpose of this study is to asses the relative influence of genetic and environmental influence on the tortuosity of retinal arterioles in eyes of 218 healthy Danish twins aged 20-46 years. We expect to find a high heredity for the variation in tortuosity. This knowledge can contribute to the elucidation of the pathology in retinal diseases.

Retinopathy of Prematurity

Study Type: Observational
Study Design: Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: Heredity of Retinal Vessel Tortuosity - A Twin Study

Resource links provided by NLM:

Further study details as provided by Glostrup University Hospital, Copenhagen:

Estimated Enrollment: 218
Study Start Date: January 1998
Estimated Study Completion Date: December 1998
Detailed Description:
All persons underwent an ophthalmic examination including refraction, slit lamp biomicroscopy and digital fundus photography. Two independent graders (both with an MD degree) made a visual grading of the severity of tortuosity of the retinal arterioles in the fundus images.

Ages Eligible for Study:   20 Years to 46 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Samesex twin pairs of self-assessed good health

Exclusion Criteria:

  • Diabetes mellitus
  • Hypertension
  • Thyroid disease
  • Cataract or other opacities of the refractive media
  • Missing fundus photographs
  Contacts and Locations
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Please refer to this study by its identifier: NCT00427063

Department of Ophthalmology Glostrup Hospital
Glostrup, Copenhagen County, Denmark, DK-2600
Sponsors and Collaborators
Glostrup University Hospital, Copenhagen
Juvenile Diabetes Research Foundation
Principal Investigator: Michael Larsen, Prof. MD Department of Ophthalmology Glostrup Hospital University of Copenhagen
  More Information Identifier: NCT00427063     History of Changes
Other Study ID Numbers: Danish Twin Registry 1998
Study First Received: January 25, 2007
Last Updated: January 25, 2007

Keywords provided by Glostrup University Hospital, Copenhagen:
retinal vessels

Additional relevant MeSH terms:
Retinopathy of Prematurity
Retinal Diseases
Eye Diseases
Infant, Premature, Diseases
Infant, Newborn, Diseases
Glucuronyl glucosamine glycan sulfate
Hypolipidemic Agents
Molecular Mechanisms of Pharmacological Action
Lipid Regulating Agents
Fibrinolytic Agents
Fibrin Modulating Agents
Hypoglycemic Agents
Physiological Effects of Drugs processed this record on June 26, 2017