Open Lung Approach During General Anaesthesia to Prevent Post-Operative Pulmonary Complications
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|ClinicalTrials.gov Identifier: NCT00426790|
Recruitment Status : Unknown
Verified January 2007 by Università degli Studi dell'Insubria.
Recruitment status was: Recruiting
First Posted : January 25, 2007
Last Update Posted : January 25, 2007
The hypothesis of this study is that the "Open lung approach" ( recruitment and PEEP) during general anaesthesia reduces atelectasis formation and improves respiratory function in the immediate post-operative period after major abdominal surgery.
This is a prospective, randomized, controlled clinical-trial,performed in patients undergoing major abdominal surgery, to compare the effects on the post-operative pulmonary complications of two different intraoperative ventilatory strategies during general anaesthesia: 1- Control Group: PEEP 0 cmH2O without recruitment manoeuvre; 2- Treatment Group:recruitment manoeuvre (after intubation and before extubation) and PEEP 10 cmH2O In the post-operative period the following variables will be recorded at the first, third and fifth postoperative day: 1- Gas-exchange in air; 2- Chest X-ray for atelectasis evaluation; 3- signs of pulmonary complication (cough, secretions, dyspnea, thoracic pain)
|Condition or disease||Intervention/treatment|
|Postoperative Complications||Procedure: Positive end-expiratory pressure|
|Study Type :||Interventional (Clinical Trial)|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00426790
|Contact: Paolo Pelosi, Professorfirstname.lastname@example.org|
|Ospedale di Circolo e Fondazione Macchi||Recruiting|
|Varese, Italy, 21100|
|Principal Investigator:||Paolo Pelosi, Professor||University of Insubria, Varese, Italy|