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Urinary Excretion of Enteroviruses From Children With a Presumed Enteroviral Infection

This study has been completed.
Information provided by:
University Hospital Inselspital, Berne Identifier:
First received: January 24, 2007
Last updated: May 18, 2011
Last verified: May 2011
Enteroviruses can infect most human organ systems, especially the heart, nervous system and pancreas. Whether Enteroviruses can also affect the kidneys is not known yet. Therefore we will analyze urine of children with a suspected enteroviral infection for enteroviruses and signs of kidney infection.

Enterovirus Infections

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective

Resource links provided by NLM:

Further study details as provided by University Hospital Inselspital, Berne:

Enrollment: 82
Study Start Date: June 2006
Study Completion Date: November 2008
Primary Completion Date: November 2008 (Final data collection date for primary outcome measure)
Detailed Description:

Enteroviruses have been shown to cause mesangioproliferation and glomerulonephritis in mice (especially coxsackievirus B4). In some cases, large amounts of IgA are deposited in the mesangium, resembling human IgA-nephropathy. In humans, case reports indicate the propensity of certain enteroviruses to cause kidney infections.

Our project aims to analyze urine of children with suspected enteroviral infections (e.g. meningitis, myocarditis, sepsis of the newborn etc.) to identify cases suspicious of concomitant enteroviral kidney affection. To achieve this aim, enterovirus-PCRs will be performed and microhematuria searched for.


Ages Eligible for Study:   up to 16 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
children age 0-16

Inclusion Criteria:

  • children, suspected of suffering from an enteroviral infection
  Contacts and Locations
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Please refer to this study by its identifier: NCT00426699

Dept. Nephrology & Hypertension, Univ. Hospital Bern
Bern, Switzerland, 3010
Sponsors and Collaborators
University Hospital Inselspital, Berne
Principal Investigator: Andreas Pasch, MD University of Bern
  More Information

Responsible Party: Andreas Pasch, Department of Nephrology and Hypertension, Inselspital, University Hospital Bern Identifier: NCT00426699     History of Changes
Other Study ID Numbers: BE002
Study First Received: January 24, 2007
Last Updated: May 18, 2011

Keywords provided by University Hospital Inselspital, Berne:

Additional relevant MeSH terms:
Enterovirus Infections
Picornaviridae Infections
RNA Virus Infections
Virus Diseases processed this record on September 19, 2017