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Urinary Excretion of Enteroviruses From Children With a Presumed Enteroviral Infection

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ClinicalTrials.gov Identifier: NCT00426699
Recruitment Status : Completed
First Posted : January 25, 2007
Last Update Posted : May 19, 2011
Sponsor:
Information provided by:
University Hospital Inselspital, Berne

Brief Summary:
Enteroviruses can infect most human organ systems, especially the heart, nervous system and pancreas. Whether Enteroviruses can also affect the kidneys is not known yet. Therefore we will analyze urine of children with a suspected enteroviral infection for enteroviruses and signs of kidney infection.

Condition or disease
Enterovirus Infections

Detailed Description:

Enteroviruses have been shown to cause mesangioproliferation and glomerulonephritis in mice (especially coxsackievirus B4). In some cases, large amounts of IgA are deposited in the mesangium, resembling human IgA-nephropathy. In humans, case reports indicate the propensity of certain enteroviruses to cause kidney infections.

Our project aims to analyze urine of children with suspected enteroviral infections (e.g. meningitis, myocarditis, sepsis of the newborn etc.) to identify cases suspicious of concomitant enteroviral kidney affection. To achieve this aim, enterovirus-PCRs will be performed and microhematuria searched for.


Study Type : Observational
Actual Enrollment : 82 participants
Observational Model: Case-Only
Time Perspective: Prospective
Study Start Date : June 2006
Actual Primary Completion Date : November 2008
Actual Study Completion Date : November 2008

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Ages Eligible for Study:   up to 16 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
children age 0-16
Criteria

Inclusion Criteria:

  • children, suspected of suffering from an enteroviral infection

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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00426699


Locations
Switzerland
Dept. Nephrology & Hypertension, Univ. Hospital Bern
Bern, Switzerland, 3010
Sponsors and Collaborators
University Hospital Inselspital, Berne
Investigators
Principal Investigator: Andreas Pasch, MD University of Bern

Responsible Party: Andreas Pasch, Department of Nephrology and Hypertension, Inselspital, University Hospital Bern
ClinicalTrials.gov Identifier: NCT00426699     History of Changes
Other Study ID Numbers: BE002
First Posted: January 25, 2007    Key Record Dates
Last Update Posted: May 19, 2011
Last Verified: May 2011

Keywords provided by University Hospital Inselspital, Berne:
enterovirus
meningitis
sepsis
myocarditis
kidney
urine
glomerulonephritis

Additional relevant MeSH terms:
Infection
Enterovirus Infections
Picornaviridae Infections
RNA Virus Infections
Virus Diseases