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Effect of Procrit (Epoetin Alfa) on Preventing Delayed Graft Function After Deceased Donor Renal Transplantation

This study has been completed.
Information provided by:
West Penn Allegheny Health System Identifier:
First received: January 18, 2007
Last updated: May 25, 2010
Last verified: May 2010
Delayed graft function (DGF) is a major complication following deceased donor renal transplantation. The surgical procedure of harvesting a kidney from a cadaveric donor and implanting the kidney into the recipient inevitably causes some amount of injury. While not always clinically significant, anywhere from 10-50% of transplant patients may develop DGF. Ongoing research in animal models has demonstrated benefit with administration of erythropoietin. The investigators propose to study the effect of Procrit(Epoetin Alfa) on delayed graft function in subjects undergoing kidney transplantation.

Condition Intervention Phase
Delayed Graft Function
Drug: Epoetin Alfa
Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Official Title: Effect of Procrit(Epoetin Alfa) on Preventing Delayed Graft Function After Deceased Donor Renal Transplantation

Resource links provided by NLM:

Further study details as provided by West Penn Allegheny Health System:

Primary Outcome Measures:
  • Decrease in Delayed Graft Function

Enrollment: 76
Study Start Date: February 2007
Study Completion Date: February 2010
Primary Completion Date: February 2010 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients presenting for kidney transplantation
  • Age > 18
  • Deceased donor kidney transplant

Exclusion Criteria:

  • History of thrombosis or hypercoagulable state
  • Receiving Coumadin or Heparin
  • Hemoglobin >=14 g/dl
  • Uncontrolled hypertension
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Please refer to this study by its identifier: NCT00425126

United States, Pennsylvania
Allegheny General Hospital
Pittsburgh, Pennsylvania, United States, 15212
Sponsors and Collaborators
West Penn Allegheny Health System
Principal Investigator: Richard J Marcus, MD West Penn Allegheny Health System
  More Information

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00425126     History of Changes
Other Study ID Numbers: RC-4044
Study First Received: January 18, 2007
Last Updated: May 25, 2010

Keywords provided by West Penn Allegheny Health System:
Delayed Graft Function
Kidney Transplantation

Additional relevant MeSH terms:
Delayed Graft Function
Pathologic Processes
Epoetin Alfa
Hematinics processed this record on May 25, 2017