Repair of Orthodontically-induced Tooth Root Resorption by Ultrasound
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|ClinicalTrials.gov Identifier: NCT00423956|
Recruitment Status : Unknown
Verified January 2013 by Tarek El-Bialy, University of Alberta, Graduate Orthodontic Program.
Recruitment status was: Recruiting
First Posted : January 18, 2007
Last Update Posted : January 23, 2013
Tooth-root resorption, also known as shortening or erosion,(TRR) is one of the adverse outcomes of dental trauma, orthodontic tooth movement and dental replantation/transplantation. Orthodontically induced inflammatory root resorption (OIIRR) is somewhat different from other types of TRR. The treatment protocol of teeth diagnosed with severe OIIRR or other forms of TRR always involves root canal treatment or extraction of these teeth in severe cases and prosthetic replacement. Sometimes teeth with minor TRR may stay for an extended period of time with compromised bite functions. Although several trials have been proposed to minimize or prevent TRR or OIIRR, none is capable of being used in clinical situation to treat TRR or OIIRR in humans except for Low Intensity Pulsed Ultrasound (LIPUS). However, research examining the use of LIPUS to treat OIIRR has been limited to simple orthodontic tooth tipping. In reality, tooth movement is a combination of different types of tooth movements, namely tipping, bodily, rotational, torque, intrusion and extrusion tooth movements. However, the literature have pointed out that torque tooth movement, especially when the root apices are torques against cortical plates of bone produces the most dramatic type of tooth root resorption with poor prognosis. Our long-term goal is to develop a standard protocol for treating severe tooth root resorption with poor prognosis in humans, regardless of origin. Our preliminary data demonstrates that LIPUS can produce healing of OIIRR in humans after simple tipping movement, this was confirmed by an in-vitro study on isolated cementoblasts. The objective of the present proposal is to evaluate the effect of different treatment protocols of LIPUS on the healing process of orthodontically induced tooth-root resorption due to torque (Complex)type of tooth movement in humans.
The study Hypotheses are (I) LIPUS treatment for 20 minutes per day for 4 weeks will be effective in repairing OIIRR due to torque tooth movement.
(II) The stimulatory effect of LIPUS to repair OIIRR due to torque tooth movement than LIPUS treatment is dose and time dependent.
|Condition or disease||Intervention/treatment||Phase|
|Root Resorption||Procedure: Repairing Induced tooth root resorption by ultrasound||Phase 1 Phase 2|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||72 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Double (Participant, Outcomes Assessor)|
|Official Title:||Repair of Orthodontically-induced Tooth Root Resorption by Ultrasound in Human Subjects|
|Study Start Date :||January 2007|
|Estimated Primary Completion Date :||December 2015|
|Estimated Study Completion Date :||December 2015|
Sham Comparator: Sham Comparator
One side is experimental and the opposite side is Sham control.
Procedure: Repairing Induced tooth root resorption by ultrasound
Repairing Induced tooth root resorption by ultrasound
- Evaluation of the effect of LIPUS on OITRR [ Time Frame: Four weeks ]
- Teeth Root length [ Time Frame: four weeks ]
- Root resorption lacunae number and volume [ Time Frame: Four weeks ]
- Study the effect of LIPUS on alveolar bone remodeling [ Time Frame: Four weeks ]
- Rate of tooth movement [ Time Frame: Rate of tooth movement at the time of extraction ]Teeth position before and after treatment will be measured to evaluate the possible effect of ultrasound on tooth movement.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00423956
|Contact: Dr. Tarek H El-Bialy, PhDemail@example.com|
|University of Alberta, Graduate Orthodontic program||Recruiting|
|Edmonton,, Alberta, Canada, T6G 2N8|
|Contact: Dr. Tarek H El-Bialy, PhD 780-492-2751 firstname.lastname@example.org|
|Study Chair:||Dr. Tarek H El-Bialy, PhD||University of Alberta, Edmonton, AB, Canada|