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First Experimental Study of Transference-Interpretations (FEST)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00423462
Recruitment Status : Completed
First Posted : January 18, 2007
Last Update Posted : August 27, 2007
The Research Council of Norway
Information provided by:
University of Oslo

Brief Summary:

Analysis of the ongoing patient-therapist interaction, the transference, is considered a key active ingredient in psychoanalytically oriented psychotherapy and psychoanalysis.However, one century after Sigmund Freuds's famous "Dora" case, the first clinical description of transference, no study of transference interpretations have been published.In the present study 100 out-patients were randomized to receive one year weekly dynamic psychotherapy, with and without transference interpretations. That is, one treatment component,transference interpretations, were added to a comparison condition, therapy of the same format, by the same therapists, but without use of transference interpretation.

All treatment session were audiotaped, and treatment integrity have been carefully checked. Patients were evaluated at treatment termination, one year after treatment termination and three years after treatment termination. Enrollment of patients started january 1993, and all follow-up evaluations completed by December 2005.

Condition or disease Intervention/treatment Phase
Mood Disorders Anxiety Disorders Personality Disorders Behavioral: Brief dynamic psychotherapy Phase 2 Phase 3

Detailed Description:

This study is designed to measure specific long-term effects of transference interpretations in dynamic psychotherapy, using an experimental dismantling design. One hundred psychiatric out-patients, referred to seven study therapists, to receive exploratory dynamic psychotherapy, were randomized to one year weekly dynamic psychotherapy, with and without transference interpretations.They suffered from mood,anxiety,and personality disorders or interpersonal problems not due to a mental disorder. All treatment sessions were audiotaped and treatment integrity carefully checked.All patients have been evaluated before treatment, after treatment, one year after termination of treatment, and three years after termination of treatment. The main outcome measures were the Psychodynamic Functioning Scales (PFS) and Inventory of Interpersonal Problems-Circumplex version (IIP-C).Chang over time is assessed using linear mixed model analyses.

The main hypothesis is that patients treated with transference interpretations will have a more favourable course over the whole study period of four years.

The second hypothesis is that suitable patients, that is patients with a life long pattern of more mature object relations (QOR) and/or patients without comorbid personality disorders will do better with transference interpretations.

Insight and identification with the therapist will be analyzed as putative mediators of long-term change in interpersonal functioning

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Study Type : Interventional  (Clinical Trial)
Enrollment : 100 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single
Primary Purpose: Treatment
Official Title: First Experimental Study of Transference Interpretations (FEST)
Study Start Date : January 1993
Study Completion Date : December 2005

Primary Outcome Measures :
  1. The Psychodynamic Functioning Scales (PFS), clinician rated
  2. Inventory if Interpersonal Problems-Circumplex version (IIP-C), self-report

Secondary Outcome Measures :
  1. The Global Assessment of Functioning Scale (GAF)
  2. Global Severity Index (GSI) from SCL-90-R

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Age 20 - 60 years
  • Diagnoses Mood-disorder, non-psychotic
  • Anxiety disorders
  • Personality disorders
  • Interpersonal problems not due to a mental disorder

Exclusion Criteria:

  • Psychotic disorders
  • Bipolar disorder
  • Organic brain disorder
  • Substance abuse
  • Long-term (years) disability
  • Mental retardation

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00423462

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Department of Psychiatry, Faculty of Medicine, University of Oslo
Oslo, Norway, 0881 Oslo
Sponsors and Collaborators
University of Oslo
The Research Council of Norway
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Principal Investigator: Per Høglend, M.D. Ph. D. Department of Psychiatry, Faculty of Medicine, Unoversity of Oslo
Publications of Results:
Publications automatically indexed to this study by Identifier (NCT Number):

Layout table for additonal information Identifier: NCT00423462    
Other Study ID Numbers: FEST307/95
First Posted: January 18, 2007    Key Record Dates
Last Update Posted: August 27, 2007
Last Verified: August 2007
Keywords provided by University of Oslo:
Long-term effects
Additional relevant MeSH terms:
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Anxiety Disorders
Personality Disorders
Mood Disorders
Pathologic Processes
Mental Disorders