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Correlation Between Cognitive Functions and MRI in Multiple Sclerosis

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified September 2007 by Sheba Medical Center.
Recruitment status was:  Recruiting
Information provided by:
Sheba Medical Center Identifier:
First received: January 15, 2007
Last updated: September 20, 2007
Last verified: September 2007
The purpose of this study is to determine whether there is a correlation between cognitive functions and volume of specific brain area measured in MRI of multiple sclerosis patients.

Multiple Sclerosis

Study Type: Observational
Study Design: Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Retrospective/Prospective

Resource links provided by NLM:

Further study details as provided by Sheba Medical Center:

Estimated Enrollment: 100
Study Start Date: February 2007
Estimated Study Completion Date: February 2009
Detailed Description:

Recent literature suggests that multiple sclerosis is accompanied by significant deficits in cognitive performance. The origin of these cognitive deficits is not known, since the severity of cognitive deficits was not found to be correlated with disease parameters such as duration, lesion load or disease intensity as measured on standard scales (e.g. EDSS). The research hypothesis we plan to test is that the individual intensity of cognitive deficits is correlated with degeneration of specific neuronal structures related to cognitive performance, such as the hippocampus and prefrontal cortex.

To test this hypothesis, we plan to perform volumetric measurements of such regions on MRI scans obtained from MS patients during the course of their clinical evaluation, and attempt to correlate those with the results of neuropsychological tests performed by the same subjects around the time of MRI scanning.


Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Clinical diagnosis of Multiple Sclerosis
  • Age 18-65

Exclusion Criteria:

  • Another brain disease
  • Stroke
  • Brain trauma
  • Neurosurgery
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00423111

Contact: Yael Deri, BSc 972 508273381
Contact: Anat Biegon, Ph.D 972 52666177

Sheba Medical Center Recruiting
Ramat Gan, Israel, 52621
Sponsors and Collaborators
Sheba Medical Center
Principal Investigator: Anat Achiron, MD Ph.D Sheba Medical Center
  More Information Identifier: NCT00423111     History of Changes
Other Study ID Numbers: SHEBA-06-4487-AA-CTIL
Study First Received: January 15, 2007
Last Updated: September 20, 2007

Keywords provided by Sheba Medical Center:
Multiple sclerosis
Cognitive deficits
Prefrontal cortex

Additional relevant MeSH terms:
Multiple Sclerosis
Pathologic Processes
Demyelinating Autoimmune Diseases, CNS
Autoimmune Diseases of the Nervous System
Nervous System Diseases
Demyelinating Diseases
Autoimmune Diseases
Immune System Diseases processed this record on September 20, 2017