Prognostic Significance of the Baroreflex Sensitivity Changes After Acute Ischemic Stroke

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.

Verified July 2008 by Far Eastern Memorial Hospital.
Recruitment status was: Recruiting

Sponsor:

Information provided by:

Far Eastern Memorial Hospital

ClinicalTrials.gov Identifier:

NCT00422474

First received: January 14, 2007

Last updated: July 8, 2008

Last verified: July 2008

History of Changes

Purpose

After acute stroke, baroreflex sensitivity (BRS) is impaired. This impaired acute stage BRS has been reported to be predictive of worsen outcome years after stroke in general. However, it is not very clear if the impaired acute stroke BRS would actually persist months after the acute stage. It is also not clear that such change, if any, would correlate with the functional outcome or prognosis after stroke.

The trial is to investigate the longitudinal time course of BRS after ischemic stroke up to the 6th month post stroke and to see if there is any correlation of the changes in BRS with the functional outcome parameters using NIHSS and mRS scores throughout this period.

Condition
Cerebrovascular Accident Baroreflexes Autonomic Nervous System Diseases


Study Type:	Observational
Study Design:	Time Perspective: Prospective
Official Title:	Noninvasive Study of the Time Course of Baroreflex Sensitivity 6-Month After Acute Ischemic Stroke and the Relation of Its Changes With Post Stroke Prognosis

Resource links provided by NLM:

MedlinePlus related topics: Allergy

U.S. FDA Resources

Further study details as provided by Far Eastern Memorial Hospital:


Estimated Enrollment:	100
Study Start Date:	January 2007

Eligibility


Ages Eligible for Study:	50 Years to 80 Years (Adult, Senior)
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Baroreflex sensitivity can be done within 72 hours of onset of acute ischemic stroke
50-80 years old
Must have either brain CT or brain MRI done

Exclusion Criteria:

NIHSS score > 10
Patient could not cooperate
Unstable vital sign
Atrial fibrillation
Transient ischemic attack patient
Diabetic patient
Impaired renal function (Cr > 2.26 mg/dl)
Unstable angina, acute myocardiac infarction, cardiomyopathy patients
Patient who has known autonomic dysfunction

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00422474

Contacts


Contact: Siupak Lee, M.D.		siupakmd@ms1.hinet.net

Locations


Taiwan
Far Eastern Memorial Hospital	Recruiting
Panchiao City, Taipei County, Taiwan, 220
Contact: Siupak Lee, M.D. siupakmd@ms1.hinet.net
Principal Investigator: Siupak Lee, M.D.
Sub-Investigator: Lung Chan, M.D.
Sub-Investigator: Dong-feng Yeih, M.D.

Sponsors and Collaborators

Far Eastern Memorial Hospital

Investigators


Principal Investigator:	Siupak Lee, M.D.	Far Eastern Memorial Hospital

More Information


Responsible Party:	Dr. Siupak Lee, Far Eastern Memorial Hospital
ClinicalTrials.gov Identifier:	NCT00422474 History of Changes
Other Study ID Numbers:	FEMH-95-C-012
Study First Received:	January 14, 2007
Last Updated:	July 8, 2008

Keywords provided by Far Eastern Memorial Hospital:


Ischemic stroke Baroreflex sensitivity Prognosis Cardiovascular autonomic regulation

Additional relevant MeSH terms:


Autonomic Nervous System Diseases Primary Dysautonomias Stroke Hypersensitivity Nervous System Diseases Cerebrovascular Disorders	Brain Diseases Central Nervous System Diseases Vascular Diseases Cardiovascular Diseases Immune System Diseases

ClinicalTrials.gov processed this record on June 26, 2017

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