Prognostic Significance of the Baroreflex Sensitivity Changes After Acute Ischemic Stroke
The recruitment status of this study is unknown because the information has not been verified recently.
Verified July 2008 by Far Eastern Memorial Hospital.
Recruitment status was Recruiting
Recruitment status was Recruiting
Sponsor:
Far Eastern Memorial Hospital
Information provided by:
Far Eastern Memorial Hospital
ClinicalTrials.gov Identifier:
NCT00422474
First received: January 14, 2007
Last updated: July 8, 2008
Last verified: July 2008
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Purpose
After acute stroke, baroreflex sensitivity (BRS) is impaired. This impaired acute stage BRS has been reported to be predictive of worsen outcome years after stroke in general. However, it is not very clear if the impaired acute stroke BRS would actually persist months after the acute stage. It is also not clear that such change, if any, would correlate with the functional outcome or prognosis after stroke.
The trial is to investigate the longitudinal time course of BRS after ischemic stroke up to the 6th month post stroke and to see if there is any correlation of the changes in BRS with the functional outcome parameters using NIHSS and mRS scores throughout this period.
| Condition |
|---|
|
Cerebrovascular Accident Baroreflexes Autonomic Nervous System Diseases |
| Study Type: | Observational |
| Study Design: | Time Perspective: Prospective |
| Official Title: | Noninvasive Study of the Time Course of Baroreflex Sensitivity 6-Month After Acute Ischemic Stroke and the Relation of Its Changes With Post Stroke Prognosis |
Resource links provided by NLM:
Further study details as provided by Far Eastern Memorial Hospital:
Eligibility| Ages Eligible for Study: | 50 Years to 80 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Criteria
Inclusion Criteria:
- Baroreflex sensitivity can be done within 72 hours of onset of acute ischemic stroke
- 50-80 years old
- Must have either brain CT or brain MRI done
Exclusion Criteria:
- NIHSS score > 10
- Patient could not cooperate
- Unstable vital sign
- Atrial fibrillation
- Transient ischemic attack patient
- Diabetic patient
- Impaired renal function (Cr > 2.26 mg/dl)
- Unstable angina, acute myocardiac infarction, cardiomyopathy patients
- Patient who has known autonomic dysfunction
Contacts and Locations
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To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00422474
Please refer to this study by its ClinicalTrials.gov identifier: NCT00422474
Contacts
| Contact: Siupak Lee, M.D. | siupakmd@ms1.hinet.net |
Locations
| Taiwan | |
| Far Eastern Memorial Hospital | Recruiting |
| Panchiao City, Taipei County, Taiwan, 220 | |
| Contact: Siupak Lee, M.D. siupakmd@ms1.hinet.net | |
| Principal Investigator: Siupak Lee, M.D. | |
| Sub-Investigator: Lung Chan, M.D. | |
| Sub-Investigator: Dong-feng Yeih, M.D. | |
Sponsors and Collaborators
Far Eastern Memorial Hospital
Investigators
| Principal Investigator: | Siupak Lee, M.D. | Far Eastern Memorial Hospital |
More Information
No publications provided
| Responsible Party: | Dr. Siupak Lee, Far Eastern Memorial Hospital |
| ClinicalTrials.gov Identifier: | NCT00422474 History of Changes |
| Other Study ID Numbers: | FEMH-95-C-012 |
| Study First Received: | January 14, 2007 |
| Last Updated: | July 8, 2008 |
| Health Authority: | Taiwan: Department of Health |
Keywords provided by Far Eastern Memorial Hospital:
|
Ischemic stroke Baroreflex sensitivity Prognosis Cardiovascular autonomic regulation |
Additional relevant MeSH terms:
|
Autonomic Nervous System Diseases Primary Dysautonomias Cerebral Infarction Nervous System Diseases Stroke Brain Diseases |
Brain Infarction Brain Ischemia Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Vascular Diseases |
ClinicalTrials.gov processed this record on March 03, 2015