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Effect of Chronic PDE5-Inhibition on Endothelial Function in Diabetics

This study has been completed.
Information provided by:
IRCCS San Raffaele Identifier:
First received: January 9, 2007
Last updated: NA
Last verified: January 2007
History: No changes posted
chronic PDE5-Inhibition improves endothelial function in diabetics

Condition Intervention Phase
Diabetes Drug: sildenafil Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment
Official Title: Effect of Chronic Administration of Sildenafil on Endothelial Function in Men With Diabetes

Resource links provided by NLM:

Further study details as provided by IRCCS San Raffaele:

Primary Outcome Measures:
  • Endothelial function responders - Improvement in endothelial function

Secondary Outcome Measures:
  • Changes in vascular inflammatory markers

Estimated Enrollment: 30
Study Start Date: January 1999
Estimated Study Completion Date: February 2000
Detailed Description:
Evaluation of endothelial function at baseline and after chronic administration of sildenafil in male subjects with diabetes

Ages Eligible for Study:   35 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • type 2 diabetes
  • males

Exclusion Criteria:

  • females, nitrate use, PDE5-Inhibitors intolerance
  Contacts and Locations
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Please refer to this study by its identifier: NCT00420901

San Raffaele EUR
Roma, Italy, 00144
Sponsors and Collaborators
IRCCS San Raffaele
Study Director: giuseppe rosano, md San Raffaele EUR
  More Information Identifier: NCT00420901     History of Changes
Other Study ID Numbers: HSRRM1999/4
Study First Received: January 9, 2007
Last Updated: January 9, 2007

Keywords provided by IRCCS San Raffaele:

Additional relevant MeSH terms:
Sildenafil Citrate
Vasodilator Agents
Phosphodiesterase 5 Inhibitors
Phosphodiesterase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Urological Agents processed this record on September 21, 2017