Effect of Exercise on the Absorption of Inhaled Human Insulin in Subjects With Type 1 Diabetes
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Ages Eligible for Study:
18 Years to 65 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Type 1 diabetes more than or equal to 12 months
Baseline HbA1c less than or equal to 11%
Body mass index (BMI) less than or equal to 29 kg/m2
Normal lung volumes
Treatment with intensified insulin therapy for at least 3 months
Any present or history of pulmonary disease
Any findings from the cardiopulmonary exercise test compromising safety of moderate exercise
Impaired hepatic or renal function
Current proliferative retinopathy or maculopathy
Treatment with drugs, which may interfere with insulin action, glucose metabolism or recovery from hypoglycaemia (judged by investigator)
Current smoking or smoking within the last 6 months
Blood donation (more than 500 mL) within the last nine weeks