Safety and Tolerability of AQW051 in Elderly Healthy Volunteers.
The purpose of this study is to assess safety and tolerability of AQW051 administered in single and multiple doses to elderly healthy volunteers. In addition, pharmacokinetic effects will be assessed and the possible effects on cognition.
|Study Design:||Allocation: Randomized
Endpoint Classification: Safety Study
Intervention Model: Parallel Assignment
Primary Purpose: Treatment
|Official Title:||A Randomized, Double-Blind, Ascending Dose, Placebo-Controlled Single Dose Study in Non-Smoking Healthy Elderly Subjects Interleaved With a 2-Week Multiple Once Daily Dose Study to Explore Safety, Tolerability, Pharmacokinetics and Cognitive Effects After Oral Administration of AQW051|
- Safety and tolerability.
- Pharmacokinetics at the end of the study.
- Effect of AQW051 on cognition as assessed by a computerized cognitive test battery.
- To assess a potential food effect on pharmacokinetics of AQW051.
- To explore the drug abuse liability potential of AQW051.
|Study Start Date:||May 2006|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00418002
|Novartis Investigative Site|
|Horsham, United Kingdom|
|Principal Investigator:||Novartis||Investigator site|