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Multifocal Electrophysiologic Findings After Intravitreal Bevacizumab(Avastin)Treatment

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ClinicalTrials.gov Identifier: NCT00417833
Recruitment Status : Completed
First Posted : January 4, 2007
Last Update Posted : October 20, 2008
Sponsor:
Information provided by:
Asociación para Evitar la Ceguera en México

Brief Summary:

Purpose: Determine the short-term safety of intravitreal bevacizumab by multifocal electroretinography (mf-ERG).

Methods: 120 eyes with choroidal neovascularization, proliferative diabetic retinopathy and retinal vein occlusion received intravitreal bevacizumab (2.5mg/0.1cc). All patients underwent best corrected visual acuity, fluorescein angiography, optical coherent tomography and mf-ERG before and 1 month after treatment.


Condition or disease Intervention/treatment Phase
Diabetic Proliferative Retinopathy Vascular Vein Oclussion Choroidal Neovascularization Drug: Intravitreal Bevacizumab Phase 2 Phase 3

Study Type : Interventional  (Clinical Trial)
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Study Start Date : December 2005
Study Completion Date : July 2006

Resource links provided by the National Library of Medicine

Drug Information available for: Bevacizumab





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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Criteria

Inclusion Criteria:

  • Proliferative diabetic retinopathy, vascular vein oclussion, choroidal neovascularization
  • Multifocal electroretinogram before intravitreal bevacizumab and at 1,3, and 6 months after treatment
  • Completely studies

Exclusion Criteria:

Complications

  • Tractional Detachment
  • Endophthalmitis

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00417833


Sponsors and Collaborators
Asociación para Evitar la Ceguera en México
Investigators
Principal Investigator: Myrian L Hernández, MD Asociación para Evitar la Ceguera en México

ClinicalTrials.gov Identifier: NCT00417833     History of Changes
Other Study ID Numbers: APEC-0017
First Posted: January 4, 2007    Key Record Dates
Last Update Posted: October 20, 2008
Last Verified: October 2008

Additional relevant MeSH terms:
Neovascularization, Pathologic
Choroidal Neovascularization
Metaplasia
Pathologic Processes
Choroid Diseases
Uveal Diseases
Eye Diseases
Bevacizumab
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
Growth Substances
Physiological Effects of Drugs
Growth Inhibitors
Antineoplastic Agents