Multifocal Electrophysiologic Findings After Intravitreal Bevacizumab(Avastin)Treatment

This study has been completed.
Information provided by:
Asociación para Evitar la Ceguera en México Identifier:
First received: January 3, 2007
Last updated: October 17, 2008
Last verified: October 2008

Purpose: Determine the short-term safety of intravitreal bevacizumab by multifocal electroretinography (mf-ERG).

Methods: 120 eyes with choroidal neovascularization, proliferative diabetic retinopathy and retinal vein occlusion received intravitreal bevacizumab (2.5mg/0.1cc). All patients underwent best corrected visual acuity, fluorescein angiography, optical coherent tomography and mf-ERG before and 1 month after treatment.

Condition Intervention Phase
Diabetic Proliferative Retinopathy
Vascular Vein Oclussion
Choroidal Neovascularization
Drug: Intravitreal Bevacizumab
Phase 2
Phase 3

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label

Resource links provided by NLM:

Further study details as provided by Asociación para Evitar la Ceguera en México:

Study Start Date: December 2005
Estimated Study Completion Date: July 2006

Genders Eligible for Study:   Both

Inclusion Criteria:

  • Proliferative diabetic retinopathy, vascular vein oclussion, choroidal neovascularization
  • Multifocal electroretinogram before intravitreal bevacizumab and at 1,3, and 6 months after treatment
  • Completely studies

Exclusion Criteria:


  • Tractional Detachment
  • Endophthalmitis
  Contacts and Locations
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Please refer to this study by its identifier: NCT00417833

Sponsors and Collaborators
Asociación para Evitar la Ceguera en México
Principal Investigator: Myrian L Hernández, MD Asociación para Evitar la Ceguera en México
  More Information

No publications provided Identifier: NCT00417833     History of Changes
Other Study ID Numbers: APEC-0017
Study First Received: January 3, 2007
Last Updated: October 17, 2008
Health Authority: México: Secretaria de Salud

Additional relevant MeSH terms:
Choroidal Neovascularization
Neovascularization, Pathologic
Choroid Diseases
Eye Diseases
Pathologic Processes
Uveal Diseases
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
Antineoplastic Agents
Growth Inhibitors
Growth Substances
Pharmacologic Actions
Physiological Effects of Drugs
Therapeutic Uses processed this record on October 02, 2015