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Multifocal Electrophysiologic Findings After Intravitreal Bevacizumab(Avastin)Treatment

This study has been completed.
Information provided by:
Asociación para Evitar la Ceguera en México Identifier:
First received: January 3, 2007
Last updated: October 17, 2008
Last verified: October 2008

Purpose: Determine the short-term safety of intravitreal bevacizumab by multifocal electroretinography (mf-ERG).

Methods: 120 eyes with choroidal neovascularization, proliferative diabetic retinopathy and retinal vein occlusion received intravitreal bevacizumab (2.5mg/0.1cc). All patients underwent best corrected visual acuity, fluorescein angiography, optical coherent tomography and mf-ERG before and 1 month after treatment.

Condition Intervention Phase
Diabetic Proliferative Retinopathy Vascular Vein Oclussion Choroidal Neovascularization Drug: Intravitreal Bevacizumab Phase 2 Phase 3

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)

Resource links provided by NLM:

Further study details as provided by Asociación para Evitar la Ceguera en México:

Study Start Date: December 2005
Estimated Study Completion Date: July 2006

Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All

Inclusion Criteria:

  • Proliferative diabetic retinopathy, vascular vein oclussion, choroidal neovascularization
  • Multifocal electroretinogram before intravitreal bevacizumab and at 1,3, and 6 months after treatment
  • Completely studies

Exclusion Criteria:


  • Tractional Detachment
  • Endophthalmitis
  Contacts and Locations
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Please refer to this study by its identifier: NCT00417833

Sponsors and Collaborators
Asociación para Evitar la Ceguera en México
Principal Investigator: Myrian L Hernández, MD Asociación para Evitar la Ceguera en México
  More Information Identifier: NCT00417833     History of Changes
Other Study ID Numbers: APEC-0017
Study First Received: January 3, 2007
Last Updated: October 17, 2008

Additional relevant MeSH terms:
Neovascularization, Pathologic
Choroidal Neovascularization
Pathologic Processes
Choroid Diseases
Uveal Diseases
Eye Diseases
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
Growth Substances
Physiological Effects of Drugs
Growth Inhibitors
Antineoplastic Agents processed this record on September 21, 2017