Primary Outcome Measures:
- Live birth per started cycle [ Time Frame: live birth ]
Secondary Outcome Measures:
- Biochemical pregnancy per started cycle [ Time Frame: positive hCG test 14 days post oocyte retrieval ]
- Clinical pregnancy per started cycle [ Time Frame: presence of fetal sac and heart beat at 7 weeks of gestation ]
- Cycle cancellation rates [ Time Frame: cycles not reaching oocyte retrieval ]
- Ongoing pregnancy rates per started cycle [ Time Frame: presence of fetal sac and heart beat at 12 weeks of gestation ]
Poor responders are a diverse group of IVF patients who fail to respond to IVF drugs. In these patients pregnancy rates remain disappointingly low and usually oocyte donation is their only viable option. The need for lengthy ovarian stimulation regimes can be avoided by performing IVF during a natural menstrual cycle. However, the main problem with a natural cycle is that successful IVF outcome can be compromised by a premature LH surge. This problem can be solved by the administration of GnRH antagonists that suppress endogenous gonadotropin levels, comprising a modified natural cycle (MNC). Previous studies have shown that MNC offers no realistic chances of pregnancy prior to oocyte donation. In this study we will re-assess this view by showing that MNC offers some, albeit small, chances of positive IVF outcome in patients with known previous poor response prior to oocyte donation.