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Effects of Roaccutane on Ca, P, PTH and Vitamin D Metabolites in the Treatment of Sever Acne

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ClinicalTrials.gov Identifier: NCT00416585
Recruitment Status : Completed
First Posted : December 28, 2006
Last Update Posted : January 23, 2008
Sponsor:
Information provided by:

Study Description
Brief Summary:
serum levels Ca, P, PTH and vitamin D metabolites before and after treatment with isotretinoin for sever acne

Condition or disease Intervention/treatment Phase
Acne Drug: isotretinoin (Roaccutane) Phase 1

Detailed Description:
few studies has been done of serum levels Ca, P, PTH and vitamin D metabolites in patients receiving isotretinoin .In this study we measured serum levels Ca, P, PTH and vitamin D metabolites before and after treatment with isotretinoin for sever acne in 30 patients . the patients had no kown skeletal, endocrine ,renal and gastrointestinal disorders.

Study Design

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 30 participants
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Effects of Roaccutane on Ca, P, PTH and Vitamin D Metabolites in the Treatment
Study Start Date : October 2005
Estimated Study Completion Date : November 2006

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Acne Vitamin D
U.S. FDA Resources

Arms and Interventions


Outcome Measures

Primary Outcome Measures :
  1. serum levels of Ca, P, PTH and vitamin D metabolites and lateral chest x-ray before the treatment

Secondary Outcome Measures :
  1. serum levels of Ca, P, PTH and vitamin D metabolites and lateral chest x-ray after the treatment

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • sever acne

Exclusion Criteria:

  • renal disorders
  • gastrointestinal disorders
  • skeletal disorders
  • endocrine disorders
  • drugs such as glucocorticoids , thiazide diuretics, mineral multivitamins, anti acids, tetracyclines
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00416585


Locations
Iran, Islamic Republic of
Shaheed Beheshti Medical University, Skin research center
Tehran, Iran, Islamic Republic of, 198994148
Sponsors and Collaborators
Shahid Beheshti University of Medical Sciences
Investigators
Study Chair: parviz toossi, md Skin Research Center
Principal Investigator: Hamideh Moravvej, md Skin Research Center
Principal Investigator: Nahid Mohtasham, md Skin Research Center
More Information

ClinicalTrials.gov Identifier: NCT00416585     History of Changes
Other Study ID Numbers: src-hmnm-1385
First Posted: December 28, 2006    Key Record Dates
Last Update Posted: January 23, 2008
Last Verified: January 2008

Keywords provided by Shahid Beheshti University of Medical Sciences:
acne
isotretinoin
calcium. vitamin D

Additional relevant MeSH terms:
Vitamins
Vitamin D
Ergocalciferols
Isotretinoin
Micronutrients
Growth Substances
Physiological Effects of Drugs
Bone Density Conservation Agents
Dermatologic Agents