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Prognostic Value of New Cardiac Biomarkers in Elderly Patients Undergoing Cardiac Surgery

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00416299
First Posted: December 27, 2006
Last Update Posted: January 30, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Klinikum Ludwigshafen
  Purpose
To evaluate the use of new cardiac biomarker for the prediction of in-hospital cardiovascular complications in elderly patients undergoing elective cardiac surgery.

Condition
Cardiac Surgery

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Observational Cohort Study on the Prognostic Value of New Cardiac Biomarkers in Elderly Patients Undergoing Cardiac Surgery

Resource links provided by NLM:


Further study details as provided by Klinikum Ludwigshafen:

Enrollment: 100
Study Start Date: May 2007
Study Completion Date: August 2007
Detailed Description:
Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP, cardiac troponin T (cTnT), pregnancy-associated plasma protein A (PAPP-A), ischemia-modified albumin (IMA), myeloperoxidase (MPO), metalloproteinase (MMP) soluble CD 40 ligand (sCD40L), and inflammatory cytokine levels will be measured in 100 elderly patients undergoing elective cardiac surgery with cardiopulmonary bypass before induction of anesthesia and 12 h, 24 h, and 48 h after surgery. Optimum discriminators for prediction of postoperative cardiovascular complications wil be determined by the use of receiver operating characteristics (ROC) curves analyses.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   75 Years and older   (Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • patients aged 75 years or older undergoing elective cardiac surgery with CPB

Exclusion Criteria:

  • positive cardiac troponin T test within the week before surgery
  • patients undergoing emergent procedures
  • patients with preoperative mechanical cardiac support
  • patients undergoing hemodialysis
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00416299


Locations
Germany
Department of Anesthesiology and Intensive Care Medicine Klinikum Ludwigshafen
Ludwigshafen, Germany, 67063
Sponsors and Collaborators
Klinikum Ludwigshafen
Investigators
Principal Investigator: Stefan W. Suttner, MD Klinikum Ludwigshafen
  More Information

ClinicalTrials.gov Identifier: NCT00416299     History of Changes
Other Study ID Numbers: KliLuNTproBNP
First Submitted: December 26, 2006
First Posted: December 27, 2006
Last Update Posted: January 30, 2009
Last Verified: January 2009

Keywords provided by Klinikum Ludwigshafen:
Cardiac biomarker
cardiac surgery
elderly
postoperative complications
Patients aged 75 years or older undergoing cardiac surgery