Prognostic Value of New Cardiac Biomarkers in Elderly Patients Undergoing Cardiac Surgery

This study has been completed.
Information provided by:
Klinikum Ludwigshafen Identifier:
First received: December 26, 2006
Last updated: January 29, 2009
Last verified: January 2009
To evaluate the use of new cardiac biomarker for the prediction of in-hospital cardiovascular complications in elderly patients undergoing elective cardiac surgery.

Cardiac Surgery

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Observational Cohort Study on the Prognostic Value of New Cardiac Biomarkers in Elderly Patients Undergoing Cardiac Surgery

Resource links provided by NLM:

Further study details as provided by Klinikum Ludwigshafen:

Enrollment: 100
Study Start Date: May 2007
Study Completion Date: August 2007
Detailed Description:
Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP, cardiac troponin T (cTnT), pregnancy-associated plasma protein A (PAPP-A), ischemia-modified albumin (IMA), myeloperoxidase (MPO), metalloproteinase (MMP) soluble CD 40 ligand (sCD40L), and inflammatory cytokine levels will be measured in 100 elderly patients undergoing elective cardiac surgery with cardiopulmonary bypass before induction of anesthesia and 12 h, 24 h, and 48 h after surgery. Optimum discriminators for prediction of postoperative cardiovascular complications wil be determined by the use of receiver operating characteristics (ROC) curves analyses.

Ages Eligible for Study:   75 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • patients aged 75 years or older undergoing elective cardiac surgery with CPB

Exclusion Criteria:

  • positive cardiac troponin T test within the week before surgery
  • patients undergoing emergent procedures
  • patients with preoperative mechanical cardiac support
  • patients undergoing hemodialysis
  Contacts and Locations
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Please refer to this study by its identifier: NCT00416299

Department of Anesthesiology and Intensive Care Medicine Klinikum Ludwigshafen
Ludwigshafen, Germany, 67063
Sponsors and Collaborators
Klinikum Ludwigshafen
Principal Investigator: Stefan W. Suttner, MD Klinikum Ludwigshafen
  More Information

No publications provided Identifier: NCT00416299     History of Changes
Other Study ID Numbers: KliLuNTproBNP
Study First Received: December 26, 2006
Last Updated: January 29, 2009
Health Authority: Germany: Federal Institute for Drugs and Medical Devices

Keywords provided by Klinikum Ludwigshafen:
Cardiac biomarker
cardiac surgery
postoperative complications
Patients aged 75 years or older undergoing cardiac surgery processed this record on November 25, 2015