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Effect of Weight Reduction on Inflammatory Markers and Genes Expression in Obese Individuals

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ClinicalTrials.gov Identifier: NCT00416156
Recruitment Status : Completed
First Posted : December 27, 2006
Last Update Posted : December 27, 2006
Information provided by:
Taichung Veterans General Hospital

Brief Summary:
To investigate whether weight reduction by life style modification for 12 weeks will improve circulating inflammatory markers, adipocytokines as well as gene expression of proinflammatory protein obtained from circulating monocytes from obese individuals.

Condition or disease Intervention/treatment
Obesity Inflammation Behavioral: Lifestyle modification

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 25 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Study Start Date : May 2005
Estimated Study Completion Date : November 2005

Primary Outcome Measures :
  1. Inflammatory responses after weight reduction

Secondary Outcome Measures :
  1. BMI
  2. Circulating inflammatory markers
  3. Adipocytokines
  4. Gene Expression from mononuclear cells

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Ages Eligible for Study:   20 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Nondiabetes obese individuals with BMI greater than 27 kgs/m2

Exclusion Criteria:

  • Diabetes
  • Abnormal hepatic, renal and cardiac function

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00416156

Taichung Veterans General Hospital
Taichung, Taiwan
Sponsors and Collaborators
Taichung Veterans General Hospital
Principal Investigator: Wayne H Sheu, MD, PhD Taichung Veterans General Hospital

ClinicalTrials.gov Identifier: NCT00416156     History of Changes
Other Study ID Numbers: TCVGH 05082
First Posted: December 27, 2006    Key Record Dates
Last Update Posted: December 27, 2006
Last Verified: December 2006

Keywords provided by Taichung Veterans General Hospital:

Additional relevant MeSH terms:
Pathologic Processes