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Effect of Weight Reduction on Inflammatory Markers and Genes Expression in Obese Individuals

This study has been completed.
Information provided by:
Taichung Veterans General Hospital Identifier:
First received: December 25, 2006
Last updated: December 26, 2006
Last verified: December 2006
To investigate whether weight reduction by life style modification for 12 weeks will improve circulating inflammatory markers, adipocytokines as well as gene expression of proinflammatory protein obtained from circulating monocytes from obese individuals.

Condition Intervention
Obesity Inflammation Behavioral: Lifestyle modification

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label

Further study details as provided by Taichung Veterans General Hospital:

Primary Outcome Measures:
  • Inflammatory responses after weight reduction

Secondary Outcome Measures:
  • BMI
  • Circulating inflammatory markers
  • Adipocytokines
  • Gene Expression from mononuclear cells

Estimated Enrollment: 25
Study Start Date: May 2005
Estimated Study Completion Date: November 2005

Ages Eligible for Study:   20 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Nondiabetes obese individuals with BMI greater than 27 kgs/m2

Exclusion Criteria:

  • Diabetes
  • Abnormal hepatic, renal and cardiac function
  Contacts and Locations
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Please refer to this study by its identifier: NCT00416156

Taichung Veterans General Hospital
Taichung, Taiwan
Sponsors and Collaborators
Taichung Veterans General Hospital
Principal Investigator: Wayne H Sheu, MD, PhD Taichung Veterans General Hospital
  More Information Identifier: NCT00416156     History of Changes
Other Study ID Numbers: TCVGH 05082
Study First Received: December 25, 2006
Last Updated: December 26, 2006

Keywords provided by Taichung Veterans General Hospital:

Additional relevant MeSH terms:
Pathologic Processes processed this record on June 23, 2017