We are updating the design of this site. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Effect of Weight Reduction on Inflammatory Markers and Genes Expression in Obese Individuals

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00416156
First Posted: December 27, 2006
Last Update Posted: December 27, 2006
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Taichung Veterans General Hospital
  Purpose
To investigate whether weight reduction by life style modification for 12 weeks will improve circulating inflammatory markers, adipocytokines as well as gene expression of proinflammatory protein obtained from circulating monocytes from obese individuals.

Condition Intervention
Obesity Inflammation Behavioral: Lifestyle modification

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)

Further study details as provided by Taichung Veterans General Hospital:

Primary Outcome Measures:
  • Inflammatory responses after weight reduction

Secondary Outcome Measures:
  • BMI
  • Circulating inflammatory markers
  • Adipocytokines
  • Gene Expression from mononuclear cells

Estimated Enrollment: 25
Study Start Date: May 2005
Estimated Study Completion Date: November 2005
  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   20 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Nondiabetes obese individuals with BMI greater than 27 kgs/m2

Exclusion Criteria:

  • Diabetes
  • Abnormal hepatic, renal and cardiac function
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00416156


Locations
Taiwan
Taichung Veterans General Hospital
Taichung, Taiwan
Sponsors and Collaborators
Taichung Veterans General Hospital
Investigators
Principal Investigator: Wayne H Sheu, MD, PhD Taichung Veterans General Hospital
  More Information

ClinicalTrials.gov Identifier: NCT00416156     History of Changes
Other Study ID Numbers: TCVGH 05082
First Submitted: December 25, 2006
First Posted: December 27, 2006
Last Update Posted: December 27, 2006
Last Verified: December 2006

Keywords provided by Taichung Veterans General Hospital:
Obesity
Inflammation

Additional relevant MeSH terms:
Inflammation
Pathologic Processes