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Neuropsychological Functioning Among Children With Tourret's Disorder and ADHD

This study has been completed.
Information provided by (Responsible Party):
National Taiwan University Hospital Identifier:
First received: December 22, 2006
Last updated: November 12, 2012
Last verified: September 2008
Tourette's disorder (TD) is a childhood-onset neuropsychiatric disorder, manifesting motor and vocal tics with increased likelihood of comorbid with attention-deficit/hyperactivity disorder (ADHD) and other psychiatric disorders. Literature documents the comorbid condition with ADHD predicts an increased functional deficit among individuals with ADHD. The information about neuropsychological functioning among individuals with TD adn/or ADHD is little in Asian population. This study aims to validate the diagnoses of TD, ADHD, and TD comorbid ADHD by symptomatology, neuropsychological measures, and social adjustment. This is a case-control study with a sample of 30 subjects with TD, 60 with ADHD, 30 with TD+ADHD, and 60 controls aged from 6 to 18. All subjects will receive comprehensive assessment including standard psychiatric diagnostic interviews using (K-SADS-E), behavioral assessments (SNAP-IV, CPRS:R-S, CTRS:R-S, CBCL, YBOCS, YGTSS), social adjustment (SAICA, GCAS), parenting (PBI, APGAR) and neuropsychological assessment (CPT, CANTAB, WISC-III). We anticipate that this study will provide the primitive data to validate the TD and ADHD using neuropsychological and clinical measures.

Tourette Disorder
Attention-Deficit/Hyperactivity Disorder

Study Type: Observational
Study Design: Observational Model: Case Control
Official Title: Neuropsychological Functioning, Symptomatology, and Social Adjustment Among Children With Tourret's Disorder, Attention-Deficit/Hyperactivity Disorder, and Comorbid Conditions.

Resource links provided by NLM:

Further study details as provided by National Taiwan University Hospital:

Enrollment: 120
Study Start Date: January 2007
Study Completion Date: December 2007

Ages Eligible for Study:   8 Years to 16 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Children with ADHD, children with ADHD and Tourette's disorder, normal control

Inclusion Criteria:

  • patients aged 8-16 without the diagnosis of ADHD, and/or Tourette's disorder
  • IQ > 80
  • both children/adolescents and their parents consent to participate and have the ability to complete self-administered measures in this study

Exclusion Criteria:

  • diagnosis of psychotic disorders, bipolar affective disorders, pervasive developmental disorder, seizure, or major physical disorders.
  • in addition, control subjects will be excluded from the control group if have a history of the following condition as defined by DSM-IV: ADHD, ODD, or CD in addition to the above exclusion criteria.
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Please refer to this study by its identifier: NCT00416091

Department of Psychiatry, National Taiwan University Hospital
Taipei, Taiwan, 1002
Sponsors and Collaborators
National Taiwan University Hospital
Principal Investigator: Susan Shur-Fen Gau, MD, PhD National Taiwan University Hospital & College of Medicine
  More Information

Barkley RA (1997), Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Psychol Bull 121: 65-94 Channon S, Pratt P, Robertson MM (2003b), Executive function, memory, and learning in Tourette's disorder. Neuropsychology 17: 247-54 Gau SS, Soong WT, Chiu YN, Tsai WC (2006a), Psychometric properties of the Chinese version of the Conners' Teacher and Parent Rating Scales-Revised Short Form. Journal of Attention Disorders. 9: 648-659 Gau SSF, Shen HY, Soong WT, Gau CS (2006b), An open-label, randomized, active controlled equivalent trial of OROS methylphenidate in children with attention-deficit/hyperactivity disorder in Taiwan. Journal of Child and Adolescent Psychopharmacology 16 (in press) Kurlan R, Whitmore D, Irvine C, McDermott MP, Como PG (1994), Tourette's disorder in a special education population: a pilot study involving a single school district. Neurology 44: 699-702

Responsible Party: National Taiwan University Hospital Identifier: NCT00416091     History of Changes
Other Study ID Numbers: 9561706006
NTUH96- S558 ( Other Identifier: National Taiwan University Hospital )
Study First Received: December 22, 2006
Last Updated: November 12, 2012

Keywords provided by National Taiwan University Hospital:
Tourette disorder, ADHD, comorbidity, neuropsychological

Additional relevant MeSH terms:
Attention Deficit Disorder with Hyperactivity
Tourette Syndrome
Pathologic Processes
Attention Deficit and Disruptive Behavior Disorders
Neurodevelopmental Disorders
Mental Disorders
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Tic Disorders
Movement Disorders
Heredodegenerative Disorders, Nervous System
Neurodegenerative Diseases
Genetic Diseases, Inborn processed this record on April 28, 2017