Relation Between Bone Density and the Regulation of Mineral Metabolism in Renal Stone Formers
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|ClinicalTrials.gov Identifier: NCT00416052|
Recruitment Status : Completed
First Posted : December 27, 2006
Last Update Posted : May 19, 2011
|Condition or disease|
There is epidemiological evidence associating renal calcium stones and decreased bone mineral density (BMD). The decreased BMD in calcium stone formers is linked to hypercalciuria and both subtypes, fasting as well as absorptive hypercalciuria are associated with a diminished BMD. Higher 1,25-vitamin D plasma concentrations and lower PTH levels are encountered under free-choice diet conditions in patients diagnosed with absorptive and fasting hypercalciuria when compared to normocalciuric stone formers. Reports studying the BMD of stone formers and its link with mineral metabolism variables and urinary calcium excretion under different calcium intakes are rare.
We hypothesize now that PTH and 1,25-vitamin D change differently when calcium stone formers with high, intermediate and low BMD are challenged by a low calcium diet.
|Study Type :||Observational|
|Estimated Enrollment :||90 participants|
|Official Title:||Relation Between Bone Mineral Density and the Regulation of Mineral Metabolism in Renal Stone Formers|
|Study Start Date :||March 2004|
|Estimated Study Completion Date :||June 2006|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00416052
|Dept. Nephrology & Hypertension, Univ. Hospital Bern|
|Bern, Switzerland, 3010|
|Study Director:||Felix J Frey, MD||University of Bern|