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Mechanism and Prevention of Remote Organ Injury Following Ruptured Aortic Aneurysm

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ClinicalTrials.gov Identifier: NCT00416000
Recruitment Status : Completed
First Posted : December 27, 2006
Last Update Posted : May 21, 2014
Sponsor:
Collaborator:
The Physicians' Services Incorporated Foundation
Information provided by (Responsible Party):
Thomas Lindsay, University Health Network, Toronto

Brief Summary:
It has been estimated that 80% of deaths from abdominal aortic aneurysms results from rupture. Endovascular Aneurysm Repair (EVAR) has been applied to RAAA (Ruptured Abdominal Aortic Aneurysm) patients with reports of improvements. Despite the use of EVAR, patients have developed complications with lung and kidney function. This study will investigate certain biochemical processes that will potentially reduce these complications. Knowledge gained from this study may also be used to further research in this field through larger studies.

Condition or disease
Abdominal Aortic Aneurysm

Study Type : Observational
Actual Enrollment : 24 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Phase 1 Study of Complement Activation Following Ruptured Abdominal Aortic Aneurysm: Combining Human Observation With Animal Experimentation to Establish a Framework for Human Therapy
Study Start Date : January 2006
Actual Primary Completion Date : June 2010
Actual Study Completion Date : December 2010

Resource links provided by the National Library of Medicine





Primary Outcome Measures :
  1. Mortality [ Time Frame: 30 days ]

Secondary Outcome Measures :
  1. multiple organ failure [ Time Frame: 30 days ]

Biospecimen Retention:   Samples Without DNA
plasma


Information from the National Library of Medicine

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Ages Eligible for Study:   30 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Those undergoing AAA repair for elevtive and ruptured AAA by both EVAR and open methods.
Criteria

Inclusion Criteria:

  • Open/Elective EVAR patients

Exclusion Criteria:

  • Patients who do not present with abdominal aortic aneurysms or ruptured abdominal aortic aneurysm

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00416000


Locations
Canada, Ontario
Toronto General Hospital
Toronto, Ontario, Canada, M5G 2C4
Sponsors and Collaborators
University Health Network, Toronto
The Physicians' Services Incorporated Foundation
Investigators
Principal Investigator: Thomas F Lindsay, MD TGH, UHN

Responsible Party: Thomas Lindsay, Professor of Surgery, University Health Network, Toronto
ClinicalTrials.gov Identifier: NCT00416000     History of Changes
Other Study ID Numbers: 06-0671B
First Posted: December 27, 2006    Key Record Dates
Last Update Posted: May 21, 2014
Last Verified: May 2014

Keywords provided by Thomas Lindsay, University Health Network, Toronto:
Open/Elective EVAR patients

Additional relevant MeSH terms:
Aneurysm
Aortic Aneurysm
Aortic Aneurysm, Abdominal
Vascular Diseases
Cardiovascular Diseases
Aortic Diseases