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Mechanism and Prevention of Remote Organ Injury Following Ruptured Aortic Aneurysm

This study has been completed.
The Physicians' Services Incorporated Foundation
Information provided by (Responsible Party):
Thomas Lindsay, University Health Network, Toronto Identifier:
First received: December 22, 2006
Last updated: May 20, 2014
Last verified: May 2014
It has been estimated that 80% of deaths from abdominal aortic aneurysms results from rupture. Endovascular Aneurysm Repair (EVAR) has been applied to RAAA (Ruptured Abdominal Aortic Aneurysm) patients with reports of improvements. Despite the use of EVAR, patients have developed complications with lung and kidney function. This study will investigate certain biochemical processes that will potentially reduce these complications. Knowledge gained from this study may also be used to further research in this field through larger studies.

Abdominal Aortic Aneurysm

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Phase 1 Study of Complement Activation Following Ruptured Abdominal Aortic Aneurysm: Combining Human Observation With Animal Experimentation to Establish a Framework for Human Therapy

Resource links provided by NLM:

Further study details as provided by Thomas Lindsay, University Health Network, Toronto:

Primary Outcome Measures:
  • Mortality [ Time Frame: 30 days ]

Secondary Outcome Measures:
  • multiple organ failure [ Time Frame: 30 days ]

Biospecimen Retention:   Samples Without DNA

Enrollment: 24
Study Start Date: January 2006
Study Completion Date: December 2010
Primary Completion Date: June 2010 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   30 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Those undergoing AAA repair for elevtive and ruptured AAA by both EVAR and open methods.

Inclusion Criteria:

  • Open/Elective EVAR patients

Exclusion Criteria:

  • Patients who do not present with abdominal aortic aneurysms or ruptured abdominal aortic aneurysm
  Contacts and Locations
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Please refer to this study by its identifier: NCT00416000

Canada, Ontario
Toronto General Hospital
Toronto, Ontario, Canada, M5G 2C4
Sponsors and Collaborators
University Health Network, Toronto
The Physicians' Services Incorporated Foundation
Principal Investigator: Thomas F Lindsay, MD TGH, UHN
  More Information

Responsible Party: Thomas Lindsay, Professor of Surgery, University Health Network, Toronto Identifier: NCT00416000     History of Changes
Other Study ID Numbers: 06-0671B
Study First Received: December 22, 2006
Last Updated: May 20, 2014

Keywords provided by Thomas Lindsay, University Health Network, Toronto:
Open/Elective EVAR patients

Additional relevant MeSH terms:
Aortic Aneurysm
Aortic Aneurysm, Abdominal
Vascular Diseases
Cardiovascular Diseases
Aortic Diseases processed this record on September 21, 2017