Impact of Respiratory Muscle Unloading on Respiratory Muscle Endurance
|ClinicalTrials.gov Identifier: NCT00415896|
Recruitment Status : Unknown
Verified December 2006 by Krankenhaus Kloster Grafschaft.
Recruitment status was: Recruiting
First Posted : December 25, 2006
Last Update Posted : December 25, 2006
|Condition or disease||Intervention/treatment|
|Chronic Respiratory Failure||Device: positive pressure ventilation|
Liberation from mechanical ventilation in difficult to wean patients is best accomplished by intermittent spontaneous breathing trials (1). Optimal respiratory muscle rest in-between breathing trials however has never been investigated.
Using a crossover design, patients are to be ventilated with complete and partial respiratory muscle unloading for a period of ten hours respectively. Respiratory muscle activity is being monitored by oesophageal balloon technique using a commercially available System (Avea, Viasys, Conshohocken, PA, USA). Time of spontaneous breathing, respiratory- and ABG parameters are being determined to characterize the course of each spontaneous breathing trial.
1. Esteban, A., F. Frutos, M. J. Tobin, I. Alia, J. F. Solsona, I. Valverdu, R. Fernandez, M. A. de la Cal, S. Benito, R. Tomas, and et al. 1995. A comparison of four methods of weaning patients from mechanical ventilation. Spanish Lung Failure Collaborative Group. N Engl J Med 332(6):345-50.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||10 participants|
|Intervention Model:||Crossover Assignment|
|Official Title:||Impact of Respiratory Muscle Unloading on Respiratory Muscle Endurance|
|Study Start Date :||December 2006|
|Estimated Study Completion Date :||June 2007|
- Endurance time
- PCO2, respiratory parameters
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00415896
|Contact: Dominic Dellweg, M.D.||+49 2972 791 ext email@example.com|
|Contact: Dieter Koehler, M.D. Prof.||+40 2972 791 ext firstname.lastname@example.org|
|Schmallenberg, Annostr. 1, Germany, 57392|
|Contact: Dominic Dellweg, M.D. +49 2972 791 ext 1257 email@example.com|
|Contact: Dieter Koehler, M.D. Prof. +49 2972 791 ext 2500 firstname.lastname@example.org|
|Sub-Investigator: Stefan Boeckling|
|Principal Investigator:||Dominic Dellweg, M.D.||FKKG|
|Study Chair:||Dieter Koehler, M.D., Prof.||FKKG|