Impact of Respiratory Muscle Unloading on Respiratory Muscle Endurance
Recruitment status was Recruiting
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Single Blind
Primary Purpose: Treatment
|Official Title:||Impact of Respiratory Muscle Unloading on Respiratory Muscle Endurance|
- Endurance time
- PCO2, respiratory parameters
|Study Start Date:||December 2006|
|Estimated Study Completion Date:||June 2007|
Liberation from mechanical ventilation in difficult to wean patients is best accomplished by intermittent spontaneous breathing trials (1). Optimal respiratory muscle rest in-between breathing trials however has never been investigated.
Using a crossover design, patients are to be ventilated with complete and partial respiratory muscle unloading for a period of ten hours respectively. Respiratory muscle activity is being monitored by oesophageal balloon technique using a commercially available System (Avea, Viasys, Conshohocken, PA, USA). Time of spontaneous breathing, respiratory- and ABG parameters are being determined to characterize the course of each spontaneous breathing trial.
1. Esteban, A., F. Frutos, M. J. Tobin, I. Alia, J. F. Solsona, I. Valverdu, R. Fernandez, M. A. de la Cal, S. Benito, R. Tomas, and et al. 1995. A comparison of four methods of weaning patients from mechanical ventilation. Spanish Lung Failure Collaborative Group. N Engl J Med 332(6):345-50.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00415896
|Contact: Dominic Dellweg, M.D.||+49 2972 791 ext email@example.com|
|Contact: Dieter Koehler, M.D. Prof.||+40 2972 791 ext firstname.lastname@example.org|
|Schmallenberg, Annostr. 1, Germany, 57392|
|Contact: Dominic Dellweg, M.D. +49 2972 791 ext 1257 email@example.com|
|Contact: Dieter Koehler, M.D. Prof. +49 2972 791 ext 2500 firstname.lastname@example.org|
|Sub-Investigator: Stefan Boeckling|
|Principal Investigator:||Dominic Dellweg, M.D.||FKKG|
|Study Chair:||Dieter Koehler, M.D., Prof.||FKKG|