Prevention Of Morbidity In Sickle Cell Disease Pilot Phase
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ClinicalTrials.gov Identifier: NCT00415727
Recruitment Status : Unknown
Verified December 2006 by Institute of Child Health. Recruitment status was: Recruiting
The hypothesis is that in sickle cell anaemia, nocturnal oxyhaemoglobin desaturation, is associated with low processing speed index, and this morbidity can be reduced with overnight auto Continuous Positive Airways Pressure and/or oxygen supplementation.
Condition or disease
Sickle Cell Anaemia
Device: auto Continuous Positive Airways Pressure (CPAP) with oxygen supplementation
Intervention: Overnight auto Continuous Positive Airways Pressure (CPAP) with oxygen supplementation if mean overnight oxyhaemoglobin saturation is not >94% after 2 weeks of autoCPAP
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Ages Eligible for Study:
4 Years to 16 Years (Child)
Sexes Eligible for Study:
Age >4 years.
Informed consent with assent in accordance with UK ethical committee(COREC) system must be signed by the patient's parent or legally authorized guardian acknowledging written consent to join the study. When suitable, patients will be requested to give their assent to join the study.
Haemoglobin SS (homozygous sickle cell anaemia) diagnosed by standard techniques. Participating institutions must submit documentation of the diagnostic haemoglobin analysis.