Absolute Myocardial Perfusion Measurement in the Transplanted Heart
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|ClinicalTrials.gov Identifier: NCT00414895|
Recruitment Status : Completed
First Posted : December 22, 2006
Last Update Posted : October 26, 2010
|Condition or disease|
Heart transplantation has become an accepted therapy for end-stage heart failure. Acute allograft rejection (AR) remains a major cause of mortality in heart transplant recipients. Chronic rejection (CR) determines the long-term prognosis after cardiac transplantation and is responsible for more than one third of late deaths. Different non-invasive methods have been evaluated for the detection of AR, but the gold standard remains endomyocardial biopsy (EMB).
Very little is known about the impact of CR on the collateral circulation in transplant patients. Since the collateral circulation of the heart is mainly part of the microcirculation, it can be hypothesized that it is less developed than in "normal" coronary atherosclerosis without microvascular lesions.
The quantification of CR with non-invasive techniques has remained difficult. In this context, there is a need for a reliable non-invasive test to avoid regularly invasive evaluation.
Based on the above considerations we propose that both AR and CR can be accurately detected and differentiated using non-invasive quantitative myocardial contrast echocardiography (MCE).
|Study Type :||Observational|
|Actual Enrollment :||90 participants|
|Official Title:||Absolute Myocardial Perfusion Measurement in the Transplanted Heart: a New Method for Accurate Detection of Allograft Rejection. A Pilot Study|
|Study Start Date :||December 2006|
|Actual Primary Completion Date :||December 2008|
|Actual Study Completion Date :||June 2009|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00414895
|University Hospital Inselspital|
|Bern, Switzerland, 3010|
|Principal Investigator:||Christian Seiler, Prof.||University Hospital Bern, Switzerland|