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Protective Effect of Coronary Collaterals on Infarct Size in Patients With Acute Myocardial Infarction

This study has been withdrawn prior to enrollment.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00412672
First Posted: December 18, 2006
Last Update Posted: June 16, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Swiss National Science Foundation
Information provided by:
University Hospital Inselspital, Berne
  Purpose

The hypothesis of the current proposal is that collateral flow is an important determinant of myocardial protection during an ischemic event. Increased collateral flow for any given area at risk will decrease the myocardial damage caused by the occlusion of the infarct related epicardial artery.

It is further hypothesized that myocardial salvage provided by collateral flow will decrease infarct size and this in turn will decrease LV dilatation post-myocardial infarction.


Condition
Myocardial Infarction

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Protective Effect of Coronary Collaterals on Infarct Size in Patients With Acute Myocardial Infarction

Resource links provided by NLM:


Further study details as provided by University Hospital Inselspital, Berne:

Enrollment: 0
Study Start Date: July 2010
Detailed Description:

The hypothesis of the current proposal is that collateral flow is an important determinant of myocardial protection during an ischemic event. Increased collateral flow for any given area at risk will decrease the myocardial damage caused by the occlusion of the infarct related epicardial artery.

It is further hypothesized that myocardial salvage provided by collateral flow will decrease infarct size and this in turn will decrease LV dilatation post-myocardial infarction.

The two primary endpoints are infarct size as assessed by increase of biochemical cardiac markers and coronary collateral perfusion index (CPI) as obtained by transthoracic MCE.

Extent of LV remodelling, i.e., LV dilatation as assessed by serial assessment of LV dimension by LV angiogram and/or echocardiography, respectively.

  Eligibility

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients with acute myocardial infarction undergoing primary PCI as reperfusion therapy of a totally occluded coronary artery.
Criteria

Inclusion Criteria:

  • Patients with acute myocardial infarction with electrocardiographic criterion and/or typical history of angina pectoris and planned revascularisation according to the acute myocardial infarction disease management guidelines of the University Hospital Bern. Including both, patients undergoing primary PCI and patients referred for rescue PCI after failed thrombolytic therapy
  • Patients > 18 years old of either sex
  • Patients who have given informed consent to the study

Exclusion Criteria:

  • Patients unable to give informed consent e.g. because of mechanical ventilation
  • Patients with cardiogenic shock
  • Patients with myocardial infarction secondary to occlusion of a recently revascularized vessel (subacute stent thrombosis)
  • Patients with severe arrhythmias
  • Patients whose door-to-balloon time exceeds 120 minutes
  • Pregnancy
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00412672


Sponsors and Collaborators
University Hospital Inselspital, Berne
Swiss National Science Foundation
Investigators
Principal Investigator: Christian Seiler, Prof. University Hospital Bern, Switzerland
  More Information

Responsible Party: Christian Seiler, MD, Professor and Co-Chairman of Cardiology, Department of Cardiology, University Hospital, CH-3010 Bern, Switzerland
ClinicalTrials.gov Identifier: NCT00412672     History of Changes
Other Study ID Numbers: 37/01
First Submitted: December 15, 2006
First Posted: December 18, 2006
Last Update Posted: June 16, 2015
Last Verified: June 2015

Keywords provided by University Hospital Inselspital, Berne:
Myocardial infarction
contrast echocardiography
collateral circulation

Additional relevant MeSH terms:
Infarction
Myocardial Infarction
Ischemia
Pathologic Processes
Necrosis
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases