Healthy Transitions: Menopause Effect on Obesity, Energy Balance, and Insulin
The purpose of this study is to determine the effect of menopause on obesity, energy balance, and insulin in postmenopausal, obese women.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Healthy Transitions: Menopause Effect on Obesity, Energy Balance, and Insulin|
|Study Start Date:||February 1998|
|Study Completion Date:||March 2007|
|Primary Completion Date:||March 2007 (Final data collection date for primary outcome measure)|
The effect of menopause on body composition and cardiovascular risk in healthy caucasian women has been the subject of much study. In contrast, there are few data available on menopause in African-American women. Since menopause is associated with potentially preventable health risks in women, this proposal is aimed at characterizing the perimenopausal period in terms of body fat, energy balance, and insulin action in both caucasian and African-American women.
The study will address 4 general hypotheses:
- Menopause increases both total and visceral abdominal fat
- Changes in body composition and body weight at menopause are mediated, at least in part by changes in 24-hour energy expenditure and/or food intake
- Menopause results in decreased insulin sensitivity that may predispose certain women to develop diabetes later in life
- African-American women may respond to the shifts in reproductive hormones at menopause differently than caucasian women.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00412269
|United States, Louisiana|
|Pennington Biomedical Research Center|
|Baton Rouge, Louisiana, United States, 70808|
|Principal Investigator:||Steven R Smith, M. D.||Pennington Biomedical Research Center|