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Insulin Resistance and Hypertensive Disorders in Pregnancy

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00412230
First Posted: December 18, 2006
Last Update Posted: February 18, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
University of Messina
  Purpose
The purpose of this study is to determine whether insulin resistance might affect the pathogenesis of hypertensive disorders in pregnancy since midtrimester. Furthermore, markers of vascular and placental injuries, of oxidative stress and inflammation will be evaluated.

Condition
Hypertension in Pregnancy Diabetes Mellitus in Pregnancy

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Retrospective
Official Title: The Role of Insulin Resistance in Gestational Hypertension and in Preeclampsia.

Resource links provided by NLM:


Further study details as provided by University of Messina:

Estimated Enrollment: 100
Study Start Date: October 2006
Study Completion Date: June 2008
Groups/Cohorts
no treatment
2

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
pregnant outpatients
Criteria

Inclusion Criteria:

  • PCOS, BMI>/=30
  • previous pregnancy affected by hypertension or gestational diabetes
  • thrombophilia
  • Type I or II diabetes mellitus
  • autoimmune diseases
  • twin pregnancy
  • renal diseases
  • previous pre-eclampsia in relatives
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00412230


Locations
Italy
University Hospital
Messina, Italy, 98121
Sponsors and Collaborators
University of Messina
Investigators
Principal Investigator: Rosario D'Anna, Associate Professor University of Messina
  More Information

Responsible Party: Rosario D'Anna, University of Messina
ClinicalTrials.gov Identifier: NCT00412230     History of Changes
Other Study ID Numbers: 120254
First Submitted: December 15, 2006
First Posted: December 18, 2006
Last Update Posted: February 18, 2009
Last Verified: February 2009

Keywords provided by University of Messina:
Pre-eclampsia
Gestational diabetes
Insulin resistance
hypertension in pregnancy

Additional relevant MeSH terms:
Hypertension
Hypertension, Pregnancy-Induced
Pregnancy in Diabetics
Pregnancy Complications
Diabetes Mellitus
Insulin Resistance
Pre-Eclampsia
Vascular Diseases
Cardiovascular Diseases
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Hyperinsulinism
Insulin
Hypoglycemic Agents
Physiological Effects of Drugs