Studies of the Prevention of Atrial Fibrillation by ALA
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Prevention
|Official Title:||Prevention of Atrial Fibrillation Recurrence By An Alpha-Linolenic Enriched Diet - A Pilot Study|
- rate of recurrence and length of time to first recurrence of atrial fibrillation.
|Study Start Date:||June 1999|
|Estimated Study Completion Date:||June 2003|
Objective: We determined the effect of an ALA rich diet in reducing recurrence of atrial fibrillation as a further example of a cardiac arrhythmia.
Design: Randomized parallel design efficacy study. Setting: Three university hospital centers in the Bordeaux region, France. Patients: 98 successive patients successfully underwent electro cardioversion of whom 75 completed the study without major deviations according to the protocol.
Intervention: A canola margarine and oil together with a Mediterranean diet (ALA ω-3, 1.4 g/d) versus a conventional diet (control), with a one year follow-up.
Main outcome measure: Length of time to first recurrence of atrial fibrillation.
Significance: If ALA is antiarrhythmic this action may explain its cardioprotective effect in clinical trials and cohort studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00410839
|Emile Roux Hospital|
|Paris, France, 94456|
|Principal Investigator:||Serge Renaud, MD, PhD||Emile Roux Hospital, A.P.H. Paris, 94456 Limeil-Brevannes, France|