Cancer Risk in X-Ray Technologists: Second Survey

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00410475
Recruitment Status : Completed
First Posted : December 13, 2006
Last Update Posted : March 22, 2018
Information provided by (Responsible Party):
National Institutes of Health Clinical Center (CC) ( National Cancer Institute (NCI) )

Brief Summary:

Researchers at the National Cancer Institute and the University of Minnesota have followed a nationwide cohort of 146,022 radiologic technologists since 1982 (Boice 1992; Doody 1998; Mohan 2003; Sigurdson 2003). This is one of the largest cohorts of medical radiation workers studied to date (Yoshinaga 2003)and the only one with substantial numbers of women (73% female), extensive covariate data, both incident and death outcomes, and estimated occupational radiation doses. The overall study objectives are to: quantify radiation dose-response for cancers of the breast, thyroid, and other radiogenic sites; assess cancer risks associated with genotypic, phenotypic, or other biologically measurable factors; and determine if genetic variation modifies radiation-related cancer risks.

More than 110,000 technologists completed at least one of three comprehensive questionnaire surveys administered over the last 20 years and 18,500 are deceased. The First Survey was mailed during 1984-1989 to 132,454 known living radiologic technologists, of whom 90,305 (68%) completed the survey (Boice 1992). The Second Survey was mailed during 1993-1998 to 126,628 known living technologists, of whom 90,972 (72%) completed the questionnaire (Sigurdson2003). Both surveys included detailed questions about employment as a radiologic technologist, family history of cancer, reproductive history, height, weight, other cancer risk factors (such as alcohol and tobacco use), history of personal diagnostic and therapeutic medical radiation procedures, and information on cancer and other health outcomes. A third follow-up of this cohort was recently completed. During 2003-2005, the Third Survey was mailed or administered by telephone to 101,694 living cohort members who had completed at least one of the two previous surveys; 73,838 technologists (73%) completed the survey. This questionnaire elicited information on medical outcomes to assess radiation-related risks, detailed calendar-specific employment data to refine the occupational ionizing radiation dose estimates, and behavioral and residential histories for estimating lifetime ultraviolet (UV) radiation exposures.

The large number of women with estimates of cumulative radiation dose to specific organs (e.g. breast) (Simon 2006; see Figure 7 and Table 9) offers at are opportunity to study effects of low-dose radiation exposure on breast and thyroid cancers, the two most sensitive organ sites for radiation carcinogenesis in women.. We are not aware of any other study population in which both quantified radiation doses and biospecimens are available for individuals with protracted low-dose ionizing radiation exposures. Incorporation of assessment of the role of genetic polymorphisms and molecular variants in DNA repair and other genetic pathways that may be functionally important in radiation carcinogenesis would provide initial results on the possible role of genetic factors in the cancer-radiation relationship. Because large numbers of women are exposed to ubiquitous low-dose radiation from occupational, medical, and environmental sources, the presence of radiation-sensitive genetic variants that influence the risk of breast and other cancers would have important public health implications.

Condition or disease
Radiation-Induced Neoplasms Breast+Neoplasm+Radiation+Etiology Thyroid+Neoplasm+Radiation+Etiology

  Show Detailed Description

Study Type : Observational
Estimated Enrollment : 146022 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Cancer Risk in X-Ray Technologists
Study Start Date : September 17, 1997

Resource links provided by the National Library of Medicine

MedlinePlus related topics: X-Rays
U.S. FDA Resources

Primary Outcome Measures :
  1. Ionizing radiation [ Time Frame: Work history information collected on questionnaires during 1983-1989, 1995-1998, 2003-2005, and 2012-2013, plus badge dose measurements from dosimetry providers for years 1960-2008, and medical outcomes collected on questionnaires and from death records ]

Secondary Outcome Measures :
  1. Ultraviolet radiation [ Time Frame: Sun exposure information collected on questionnaires during 2003-2005; medical outcomes collected on questionnaires during 2012-2013 and from death records ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 110 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Medical x-ray technologists certified (at least two years during 1926-1982) by the American Registry of Radiologic Technicians (ARRT).

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00410475

United States, Minnesota
University of Minnesota
Minneapolis, Minnesota, United States, 55415
Sponsors and Collaborators
National Cancer Institute (NCI)
Principal Investigator: Martha Linet, M.D. National Cancer Institute (NCI)

Responsible Party: National Cancer Institute (NCI) Identifier: NCT00410475     History of Changes
Other Study ID Numbers: 999997053
First Posted: December 13, 2006    Key Record Dates
Last Update Posted: March 22, 2018
Last Verified: April 19, 2017

Keywords provided by National Institutes of Health Clinical Center (CC) ( National Cancer Institute (NCI) ):
Ionizing Radiation
Cohort Study
Radiation-Induced Neoplasms
Radiologic Technologists
Ultraviolet Radiation

Additional relevant MeSH terms:
Neoplasms, Radiation-Induced
Radiation Injuries
Wounds and Injuries