A Randomized, Controlled, Unblinded, Clinical Trial of the Acceptability and Efficacy of Non-Pharmaceutical Methods in Preventing Spread of Influenza Within the Family
|ClinicalTrials.gov Identifier: NCT00410176|
Recruitment Status : Unknown
Verified December 2006 by Ministry of Health, Israel.
Recruitment status was: Not yet recruiting
First Posted : December 12, 2006
Last Update Posted : December 12, 2006
The proposed study will evaluate whether the use of non-pharmaceutical methods, such as surgical masks, isolation of patients and personal hygiene, are acceptable and effective in preventing the spread of influenza within the family.This will be achieved by conducting a randomized, controlled, unblinded, clinical trial. Family members of an index case with influenza like illness, will be randomly allocated to two groups. In the intervention group, family members will receive comprehensive guidance about sanitation and hygiene, as well as surgical masks to wear whenever in close contact (3 feet / 1 meter) with the index case. In addition, they will be asked to isolate the index case as much as possible. In the control group, family members will receive only standard guidance about sanitation and hygiene relevant for reducing the transmission of influenza. The primary end-point of the study will be secondary infection of influenza of at least one of the family members in order to asses the efficacy of the interventions. In addition, the compliance to those interventions will be evaluated.
The study hypothesis is that use of non-pharmaceutical methods will be acceptable and will reduce the secondary infection rate among them by 50%.
|Condition or disease||Intervention/treatment||Phase|
|Influenza||Behavioral: sanitation and personal hygiene||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||400 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Study Start Date :||January 2007|
- secondary infection of influenza within the family
- compliance of non-pharmaceutical interventions
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00410176
|Contact: Manfred S Green, PhD, M.D||972-3-7371500 ext email@example.com|
|Principal Investigator:||Manfred S Green, PhD, M.D||ICDC|