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Pathogenesis and Cerebrovascular Manifestations of Septic Encephalopathy

This study has been completed.
Information provided by:
University Hospital, Basel, Switzerland Identifier:
First received: December 11, 2006
Last updated: October 15, 2008
Last verified: October 2008

Septic encephalopathy is an important complication of sepsis. Why some patients with sepsis develop septic encephalopathy is unknown. We will investigate whether patients who develop this condition have different patterns of cerebrovascular reactivity and whether it is possible to predict the development of septic encephalopathy from early measurements of cerebral perfusion or from the EEG. We will specifically test the hypotheses that septic encephalopathy may not be predicted by changes in the EEG, and that cerebrovascular autoregulation is not dysfunctional in septic encephalopathy.


Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: A Pilotstudy on Pathogenesis and Cerebrovascular Manifestations of Septic Encephalopathy

Resource links provided by NLM:

Further study details as provided by University Hospital, Basel, Switzerland:

Enrollment: 23
Study Start Date: January 2007
Study Completion Date: July 2007

Ages Eligible for Study:   16 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Patients with sepsis, severe sepsis or septic shock admitted to an intensive care unit


Inclusion Criteria:

  • Sepsis
  • Admission to ICU

Exclusion Criteria:

  • CNS infection
  • History of cerebrovascular disease
  Contacts and Locations
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Please refer to this study by its identifier: NCT00410111

Operative Intensivbehandlung, University of Basel Hospital
Basel, Switzerland, 4031
Sponsors and Collaborators
University Hospital, Basel, Switzerland
Principal Investigator: Luzius A Steiner, MD PhD Department of Anesthesia, University of Basel Hospital, Basel, Switzerland
  More Information

No publications provided by University Hospital, Basel, Switzerland

Additional publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00410111     History of Changes
Other Study ID Numbers: EKBB 226/06
Study First Received: December 11, 2006
Last Updated: October 15, 2008
Health Authority: Switzerland: Federal Office of Public Health

Keywords provided by University Hospital, Basel, Switzerland:
cerebral perfusion
electroencephalogram processed this record on March 03, 2015