Pathogenesis and Cerebrovascular Manifestations of Septic Encephalopathy

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00410111
Recruitment Status : Completed
First Posted : December 12, 2006
Last Update Posted : October 16, 2008
Information provided by:
University Hospital, Basel, Switzerland

Brief Summary:
Septic encephalopathy is an important complication of sepsis. Why some patients with sepsis develop septic encephalopathy is unknown. We will investigate whether patients who develop this condition have different patterns of cerebrovascular reactivity and whether it is possible to predict the development of septic encephalopathy from early measurements of cerebral perfusion or from the EEG. We will specifically test the hypotheses that septic encephalopathy may not be predicted by changes in the EEG, and that cerebrovascular autoregulation is not dysfunctional in septic encephalopathy.

Condition or disease

Study Type : Observational
Actual Enrollment : 23 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: A Pilotstudy on Pathogenesis and Cerebrovascular Manifestations of Septic Encephalopathy
Study Start Date : January 2007
Study Completion Date : July 2007

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Sepsis
U.S. FDA Resources

Information from the National Library of Medicine

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Ages Eligible for Study:   16 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with sepsis, severe sepsis or septic shock admitted to an intensive care unit

Inclusion Criteria:

  • Sepsis
  • Admission to ICU

Exclusion Criteria:

  • CNS infection
  • History of cerebrovascular disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00410111

Operative Intensivbehandlung, University of Basel Hospital
Basel, Switzerland, 4031
Sponsors and Collaborators
University Hospital, Basel, Switzerland
Principal Investigator: Luzius A Steiner, MD PhD Department of Anesthesia, University of Basel Hospital, Basel, Switzerland

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00410111     History of Changes
Other Study ID Numbers: EKBB 226/06
First Posted: December 12, 2006    Key Record Dates
Last Update Posted: October 16, 2008
Last Verified: October 2008

Keywords provided by University Hospital, Basel, Switzerland:
cerebral perfusion

Additional relevant MeSH terms:
Brain Diseases
Sepsis-Associated Encephalopathy
Systemic Inflammatory Response Syndrome
Pathologic Processes
Central Nervous System Diseases
Nervous System Diseases