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Pathogenesis and Cerebrovascular Manifestations of Septic Encephalopathy

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00410111
First Posted: December 12, 2006
Last Update Posted: October 16, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
University Hospital, Basel, Switzerland
  Purpose
Septic encephalopathy is an important complication of sepsis. Why some patients with sepsis develop septic encephalopathy is unknown. We will investigate whether patients who develop this condition have different patterns of cerebrovascular reactivity and whether it is possible to predict the development of septic encephalopathy from early measurements of cerebral perfusion or from the EEG. We will specifically test the hypotheses that septic encephalopathy may not be predicted by changes in the EEG, and that cerebrovascular autoregulation is not dysfunctional in septic encephalopathy.

Condition
Sepsis

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: A Pilotstudy on Pathogenesis and Cerebrovascular Manifestations of Septic Encephalopathy

Resource links provided by NLM:


Further study details as provided by University Hospital, Basel, Switzerland:

Enrollment: 23
Study Start Date: January 2007
Study Completion Date: July 2007
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   16 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with sepsis, severe sepsis or septic shock admitted to an intensive care unit
Criteria

Inclusion Criteria:

  • Sepsis
  • Admission to ICU

Exclusion Criteria:

  • CNS infection
  • History of cerebrovascular disease
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00410111


Locations
Switzerland
Operative Intensivbehandlung, University of Basel Hospital
Basel, Switzerland, 4031
Sponsors and Collaborators
University Hospital, Basel, Switzerland
Investigators
Principal Investigator: Luzius A Steiner, MD PhD Department of Anesthesia, University of Basel Hospital, Basel, Switzerland
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00410111     History of Changes
Other Study ID Numbers: EKBB 226/06
First Submitted: December 11, 2006
First Posted: December 12, 2006
Last Update Posted: October 16, 2008
Last Verified: October 2008

Keywords provided by University Hospital, Basel, Switzerland:
sepsis
encephalopathy
cerebral perfusion
electroencephalogram

Additional relevant MeSH terms:
Sepsis
Brain Diseases
Sepsis-Associated Encephalopathy
Infection
Systemic Inflammatory Response Syndrome
Inflammation
Pathologic Processes
Central Nervous System Diseases
Nervous System Diseases