Renal Hemodynamics and Tubular Function in Patients With Obstructive Sleep Apnea and Healthy Controls
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|ClinicalTrials.gov Identifier: NCT00410085|
Recruitment Status : Completed
First Posted : December 12, 2006
Last Update Posted : April 22, 2008
Nitrogen-oxide (NO) plays an important role for blood pressure regulation, renal hemodynamics, and the renal excretion of sodium. NO is synthesized from L-arginine in the vascular endothelium and have a very short half-life in plasma and is therefore very difficult to measure directly.
L-mono-methyl-L-arginine (L-NMMA) is an analogue to L-arginine and a competitive inhibitor of NO, and therefore can be used to study the effect of NO on the circulation. In normal subjects, infusion of L-NMMA will cause an increase in blood pressure, decreased renal plasma-flow, decreased glomerular filtration rate, and a decreased excretion of sodium.
Hypothesis: Patients with obstructive sleep apnea has a decreased activity in the NO-system. This is contributing to the hypertension often seen in these patients. Decreased activity in the NO-system can be revealed by diminished fall in renal hemodynamic and sodium excretion after infusion of L-NMMA.
|Condition or disease||Intervention/treatment||Phase|
|Obstructive Sleep Apnea Healthy||Drug: L-NMMA (N-mono.methyl-L-arginine)||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||40 participants|
|Intervention Model:||Crossover Assignment|
|Primary Purpose:||Basic Science|
|Study Start Date :||January 2005|
|Study Completion Date :||November 2005|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00410085
|Department of Medical Research, Holstebro Hospital|
|Holstebro, Ringkoebing County, Denmark, 7500|
|Study Chair:||Erling B Pedersen, Professor||Regional Hospital Holstebro|