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Local Infiltration Analgesia With Ropivacaine Versus Placebo in Bilateral Knee Arthroplasty

This study has been completed.
Information provided by:
Hvidovre University Hospital Identifier:
First received: December 6, 2006
Last updated: February 28, 2008
Last verified: February 2008
The purpose of this study is to examine whether local infiltration analgesia (LIA) with Ropivacaine and adrenaline is effective in the treatment of postoperative pain after total knee arthroplasty.

Condition Intervention Phase
Postoperative Pain Procedure: local infiltration analgesia Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double
Primary Purpose: Treatment
Official Title: Local Infiltration Analgesia With Ropivacaine Versus Placebo in Bilateral Knee Arthroplasty: a Placebo Controlled, Randomized, Double-Blinded Study.

Resource links provided by NLM:

Further study details as provided by Hvidovre University Hospital:

Primary Outcome Measures:
  • Postoperative pain

Secondary Outcome Measures:
  • analgésia consumption
  • time to discharge

Estimated Enrollment: 16
Study Start Date: September 2006
Study Completion Date: December 2006
Detailed Description:
Total knee arthroplasty (TKA) is increasingly common in the treatment of osteoarthrosis. Despite aggressive analgesic regimes, TKA is associated with moderate to severe postoperative pain, delaying mobilization and hospital discharge. A relatively new method for controlling postoperative pain after TKA is local infiltration analgesia (LIA) which consists of local infiltration with Ropivacaine and adrenaline.3 studies haved showed promising results of LIA, but none have documented a superior analgesic effect versus placebo.Patients receiving bilateral knee arthroplasty are recruited to receive LIA and placebo infiltration.The aim of the study is to demonstrate an analgesic effect of LIA versus placebo.

Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • patients eligible for total knee arthroplasty
  • must speak and understand Danish
  • must be able to give oral and written consent

Exclusion Criteria:

  • Alcohol or medicine abuse
  • Treatment with opioids
  • Allergy to local anaesthetics
  • Severe obesity
  Contacts and Locations
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Please refer to this study by its identifier: NCT00408707

Hvidovre University Hospital
Hvidovre, Denmark, 2650
Sponsors and Collaborators
Hvidovre University Hospital
Principal Investigator: Lasse Andersen, M.D. Hvidovre University Hospital
  More Information

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00408707     History of Changes
Other Study ID Numbers: KF01320120
Study First Received: December 6, 2006
Last Updated: February 28, 2008

Keywords provided by Hvidovre University Hospital:
local infiltration analgesia
postoperative pain

Additional relevant MeSH terms:
Pain, Postoperative
Neurologic Manifestations
Nervous System Diseases
Postoperative Complications
Pathologic Processes
Signs and Symptoms
Anesthetics, Local
Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents processed this record on September 21, 2017